1070443-92-3Relevant academic research and scientific papers
A formal enantioselective acetate mannich reaction: The nitro functional group as a traceless agent for activation and enantiocontrol in the synthesis of β-amino acids
Shen, Bo,Johnston, Jeffrey N.
supporting information; experimental part, p. 4397 - 4400 (2009/05/07)
(Chemical Equation) A two-step procedure involving the enantioselectlve addition of α-nitro esters to imines, followed by reductive denitration, provides a convenient new enantioselective synthesis of β-amino acids. Specifically, β-phenyl alanine derivatives with up to 98% ee are formed In good yield (64-88%) over two steps. The utility of the approach is demonstrated through the first enantioselective synthesis of the key β-amino acid of (+)-chaenorhine.
