107057-96-5Relevant academic research and scientific papers
Ultrasound-assisted one-pot synthesis of substituted coumarins catalyzed by poly(4-vinylpyridinium) hydrogen sulfate as an efficient and reusable solid acid catalyst
Khaligh, Nader Ghaffari
, p. 1062 - 1068 (2013/04/24)
Poly(4-vinylpyridinium) hydrogen sulfate solid acid was found to be efficient catalyst for synthesis of substituted coumarins via Pechmann reaction using ultrasound irradiation at room temperature and neat condition in high yields with short reaction times. This methodology offers momentous improvements over various options for the synthesis of coumarins with regard to yield of products, simplicity in operation and green aspects by avoiding toxic catalysts and solvents. Further, the catalyst can be reused and recovered for several times.
Succinimide-N-sulfonic acid catalyzed synthesis of bis(indolyl)methane and coumarin derivatives under mild conditions
Shirini, Farhad,Khaligh, Nader Ghaffari
, p. 1890 - 1896 (2013/11/19)
A mild and simple procedure is described for the synthesis of bis(indolyl)methane and coumarin derivatives using succinimide-N-sulfonic acid as an efficient, cheap, and reusable catalyst under mild conditions.
A solvent-free synthesis of coumarins using a Wells-Dawson heteropolyacid as catalyst
Romanelli,Bennardi,Ruiz,Baronetti,Thomas,Autino
, p. 8935 - 8939 (2007/10/03)
Seventeen examples are resolved, most of them in good to excellent yields, using the cheap WD catalyst. Substituted coumarins are synthesized from phenols and β-ketoesters by the Pechmann reaction, using a Wells-Dawson heteropolyacid (H6P2W18O62? 24H2O) as catalyst by a solvent-free procedure. This one requires low reaction times, 130°C temperature and as little as 1 mol % of Wells-Dawson acid, obtaining good to excellent yields of coumarins. The catalyst showed to be reusable with no differences in the yields. The results are compared with those of the reactions performed in toluene solution. The presented synthetic procedure is a convenient, clean and fast alternative for synthesizing 4-substituted coumarins (17 examples).
Synthesis of 7-Ethoxy-3,4-dimethylcoumarin and 5-Methoxy-4-methylcoumarin
Ahluwalia, V. K.,Mehta, Vimal D.,Khanduri, C. H.
, p. 68 - 69 (2007/10/02)
The structures proposed for two new naturally occuring coumarins as 7-ethoxy-3,4-dimethylcoumarin (1a) and 5-methoxy-4-methylcoumarin (2) (isolated from Edgeworthia gardneri) have been confirmed by their syntheses.
Chloromethylation of Some Alkylcoumarins
Gawande, Prabha
, p. 81 - 83 (2007/10/02)
Chloromethylation of coumarins proceeds smoothly when there is a methyl group at 4-position to give 3-chloromethyl derivatives. 4,6,7-Trimethyl-, 4,5,7-trimethyl-, 5-hydroxy-4,7-dimethyl-, 6,7-dimethyl-, 5,7-dimethyl- and 7-hydroxy-5-methyl-coumarins and 4'-methylnaphtho-α-pyrone have been subjected to chloromethylation using paraformaldehyde and dry hydrochloric acid gas.The chloromethyl derivatives obtained have been used further for the synthesis of other derivatives.
