107058-33-3Relevant academic research and scientific papers
Solvatochromism and intramolecular charge transfer in dialkylamino-substituted halogenated thienyl chalcone analogues
Echevarria, Lorenzo,Fernández-Terán, Ricardo,Hernández, Florencio Eloy,Sucre-Rosales, Estefanía,Urdaneta, Neudo
, (2020)
Herein, we present the study of two complementary intramolecular charge transfer (ICT) transitions in two sets of dialkylamino-substituted halogenated thienyl chalcones. We demonstrate that while the first (and stronger) ICT takes place from the 4-(dialkylamino)phenyl moiety to the enone, the second ICT involves the thienyl substituent as the donor. The former is evidenced by a robust solvatochromic shift in both absorption and emission spectra, implying a large increase in the dipole moment upon excitation to the lowest excited state. The latter, a short-range ICT process, is confirmed upon photoexcitation of the higher energy bands, and its enhancement by the larger polarizability of the iodine substituent. With the help of (TD)-DFT calculations and the solvatochromic method, we quantified the extent of these effects and set the stage for further developments towards the design of new chalcone-based dyes. We demonstrated that theoretical calculations allow fine-tuning the sensitive balance between these complementary ICT processes.
Exploration of chlorinated thienyl chalcones: A new class of monoamine oxidase-B inhibitors
Mathew, Bijo,Haridas, Abitha,U?ar, Gülberk,Baysal, Ipek,Adeniyi, Adebayo A.,Soliman, Mahmoud E.S.,Joy, Monu,Mathew, Githa Elizabeth,Lakshmanan, Baskar,Jayaprakash, Venkatesan
, p. 680 - 695 (2016)
Chalcone has been reported to be a valid scaffold for the design of monoamine oxidase (MAO) inhibitors. This scenario has amplified the momentum for the discovery of heteroaryl based chalcone MAO inhibitors. In the present study, we have synthesized a ser
