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2-Acetyl-5-chlorothiophene Manufacturer/High quality/Best price/In stock
Cas No: 6310-09-4
USD $ 3.0-3.0 / Kilogram 1 Kilogram 1-100 Metric Ton/Month Dayang Chem (Hangzhou) Co.,Ltd. Contact Supplier
6310-09-4 Ethanone,1-(5-chloro-2-thienyl)-
Cas No: 6310-09-4
USD $ 40.0-50.0 / Gram 1 Gram 1000 Metric Ton/Day WUHAN MULEI NEW MATERIAL CO., LTD Contact Supplier
2-Acetyl-5-chlorothiophene
Cas No: 6310-09-4
No Data 10 Milligram Amadis Chemical Co., Ltd. Contact Supplier
2-Acetyl-5-chlorothiophene
Cas No: 6310-09-4
No Data No Data No Data Chemwill Asia Co., Ltd. Contact Supplier
2-Acetyl-5-chlorothiophene/C6H5ClOS CAS 6310-09-4
Cas No: 6310-09-4
No Data 100 Gram 20000 Kilogram/Day Hubei XinRunde Chemical Co., Ltd Contact Supplier
Top Purity CAS 6310-09-4 with fast shipping
Cas No: 6310-09-4
USD $ 139.0-210.0 / Kilogram 1 Kilogram 1000 Kilogram/Day Zhuozhou Wenxi import and Export Co., Ltd Contact Supplier
Ethanone,1-(5-chloro-2-thienyl)- 6310-09-4
Cas No: 6310-09-4
No Data 1 Kilogram 10000 Metric Ton/Month Shanghai Upbio Tech Co.,Ltd Contact Supplier
CAS NO.6310-09-4 Ethanone,1-(5-chloro-2-thienyl)-
Cas No: 6310-09-4
USD $ 50.0-100.0 / Gram 1 Gram 10000 Metric Ton/Month Wuhan Monad Medicine Tech Co.,LTD Contact Supplier
Ethanone,1-(5-chloro-2-thienyl)-
Cas No: 6310-09-4
No Data No Data No Data Shandong Hanjiang Chemical Co., Ltd. Contact Supplier
2-ACETYL-5-CHLOROTHIOPHENE / in bulk and high quality
Cas No: 6310-09-4
USD $ 1.0-1.0 / Kilogram 1 Kilogram 100 Kilogram/Day Career Henan Chemical Co Contact Supplier

6310-09-4 Usage

Chemical Properties

white to light yellow crystal powder
InChI:InChI=1/C6H5ClOS/c1-4(8)5-2-3-6(7)9-5/h2-3H,1H3

6310-09-4 Well-known Company Product Price

Brand (Code)Product description CAS number Packaging Price Detail
Aldrich (247073)  2-Acetyl-5-chlorothiophene  99% 6310-09-4 247073-25G 1,112.67CNY Detail
Aldrich (247073)  2-Acetyl-5-chlorothiophene  99% 6310-09-4 247073-5G 358.02CNY Detail
Alfa Aesar (A11850)  2-Acetyl-5-chlorothiophene, 99%    6310-09-4 250g 5196.0CNY Detail
Alfa Aesar (A11850)  2-Acetyl-5-chlorothiophene, 99%    6310-09-4 50g 1119.0CNY Detail
Alfa Aesar (A11850)  2-Acetyl-5-chlorothiophene, 99%    6310-09-4 10g 282.0CNY Detail

6310-09-4SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 12, 2017

Revision Date: Aug 12, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Acetyl-5-chlorothiophene

1.2 Other means of identification

Product number -
Other names 1-(5-chlorothiophen-2-yl)ethanone

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:6310-09-4 SDS

6310-09-4Synthetic route

5-chloro-2-(α-methoxyimino)ethylthiophene
114774-04-8

5-chloro-2-(α-methoxyimino)ethylthiophene

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
With hydrogenchloride at 70℃; for 8h;96%
2-thienyl chloride
96-43-5

2-thienyl chloride

acetyl chloride
75-36-5

acetyl chloride

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
With ytterbium(III) triflate In nitromethane at 20℃; for 4h; Friedel-Crafts acylation;90%
With zinc trifluoromethanesulfonate In nitromethane at 20℃; for 4h; Friedel-Crafts acylation;87%
With tetrachloromethane; aluminium trichloride
With aluminium trichloride; Petroleum ether Behandeln des Reaktionsprodukts mit Wasser;
Stage #1: acetyl chloride With aluminum (III) chloride In tetrachloromethane at 0℃; for 0.333333h; Friedel Crafts Acylation;
Stage #2: 2-thienyl chloride In tetrachloromethane at 0℃; for 1.58333h; Friedel Crafts Acylation;
Stage #3: With hydrogenchloride; water In tetrachloromethane
2-thienyl chloride
96-43-5

2-thienyl chloride

acetic anhydride
108-24-7

acetic anhydride

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
With perchloric acid at 0 - 20℃; for 6.5h;81%
activated clay at 45 - 55℃; for 73h;52%
With phosphoric acid
2-Acetylthiophene
88-15-3

2-Acetylthiophene

A

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

B

2-acetyl-5-iodothiophene
30955-94-3

2-acetyl-5-iodothiophene

Conditions
ConditionsYield
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h;A 69%
B 7%
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h; Product distribution; with different molar ratio;A 47%
B 22%
With N,N,N-trimethylbenzenemethanaminium dichloroiodate; zinc(II) chloride In acetic acid at 70℃; for 24h;A 47%
B 22%
2-thienyl chloride
96-43-5

2-thienyl chloride

acetic anhydride
108-24-7

acetic anhydride

trifluoroborane diethyl ether
109-63-7

trifluoroborane diethyl ether

A

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

B

1-(5-chloro-[2]thienyl)-butane-1,3-dione

1-(5-chloro-[2]thienyl)-butane-1,3-dione

C

(E)-1,3-bis-(5-chlorothien-2-yl)but-2-en-1-one

(E)-1,3-bis-(5-chlorothien-2-yl)but-2-en-1-one

C6H4(3)HClOS

C6H4(3)HClOS

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
sodium hydroxide at 25℃; Rate constant;
2-Acetylthiophene
88-15-3

2-Acetylthiophene

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 81 percent / Na2CO3, AcOH / methanol; H2O / 2 h / Heating; pH 4.5
2: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating
3: 96 percent / 25percent HCl / 8 h / 70 °C
View Scheme
Multi-step reaction with 4 steps
1: 98 percent / NH2OH*HCl, Na2CO3, AcOH / methanol; H2O / 2 h / Heating
2: 95 percent / NaOH / dimethylformamide; H2O / 0.5 h / 10 °C
3: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating
4: 96 percent / 25percent HCl / 8 h / 70 °C
View Scheme
2-acetylthiophene oxime
1956-45-2, 92313-45-6, 92313-54-7

2-acetylthiophene oxime

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
Multi-step reaction with 3 steps
1: 95 percent / NaOH / dimethylformamide; H2O / 0.5 h / 10 °C
2: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating
3: 96 percent / 25percent HCl / 8 h / 70 °C
View Scheme
2-(α-methoxyimino)ethylthiophene
114773-97-6

2-(α-methoxyimino)ethylthiophene

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
Multi-step reaction with 2 steps
1: 62 percent / Fe, Cl2 / CHCl3 / 3 h / Heating
2: 96 percent / 25percent HCl / 8 h / 70 °C
View Scheme
5-chloro-2-(α-methoxyimino)ethylthiophene

5-chloro-2-(α-methoxyimino)ethylthiophene

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Conditions
ConditionsYield
With hydrogenchloride
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

2-Methylphenylboronic acid
16419-60-6

2-Methylphenylboronic acid

1‐[5‐(2‐methylphenyl)‐2‐thienyl]ethanone

1‐[5‐(2‐methylphenyl)‐2‐thienyl]ethanone

Conditions
ConditionsYield
With potassium fluoride; tris(dibenzylideneacetone)dipalladium (0); tri-tert-butyl phosphine In tetrahydrofuran; hexane at 20℃; for 7h; Suzuki cross-coupling;99%
With potassium phosphate monohydrate; 2‐(dicyclohexylphosphino)‐N,N‐diisopropyl‐5,6‐dimethyl‐1H‐benzo[d]imidazole‐1‐carboxamide; palladium diacetate In tetrahydrofuran at 110℃; for 24h; Suzuki-Miyaura Coupling; Schlenk technique; Inert atmosphere; Sealed tube;98%
With potassium methanolate; tetrabutylammomium bromide; 1,3-bis[2,6-diisopropylphenyl]imidazolium chloride; bis(dibenzylideneacetone)-palladium(0) In methanol; toluene at 40℃; for 29h; Suzuki-Miyaura cross-coupling reaction;61%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

trans-2-phenylvinylboronic acid
6783-05-7

trans-2-phenylvinylboronic acid

trans-2-acetyl-5-(β-phenylvinyl)thiophene
125972-78-3

trans-2-acetyl-5-(β-phenylvinyl)thiophene

Conditions
ConditionsYield
With potassium carbonate; 3-Cl-pyridine-Pd-{CH-[N-(2,6-di-iPrC6H3)-CH]2}Cl2 In 1,4-dioxane at 60℃; for 6h; Suzuki-Miyaura reaction;99%
With tris-(dibenzylideneacetone)dipalladium(0); potassium fluoride dihydrate; tri-tert-butylphosphonium tetrafluoroborate In tetrahydrofuran at 20℃; Suzuki cross-coupling; Inert atmosphere;90%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

Dihydroxy-styryl-boran
4363-35-3, 6783-05-7, 60806-02-2

Dihydroxy-styryl-boran

trans-2-acetyl-5-(β-phenylvinyl)thiophene
125972-78-3

trans-2-acetyl-5-(β-phenylvinyl)thiophene

Conditions
ConditionsYield
With potassium carbonate; [1,3-bis(2,6-diisopropylphenyl)imidazol-2-ylidene](3-chloropyridyl)palladium(II) dichloride In 1,4-dioxane at 60℃; for 6h; Product distribution / selectivity; Suzuki Coupling;99%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

2-(tributylstannyl)furan
118486-94-5

2-(tributylstannyl)furan

1-(5-(furan-2-yl)-thiophen-2-yl)ethanone
879896-51-2

1-(5-(furan-2-yl)-thiophen-2-yl)ethanone

Conditions
ConditionsYield
With trans-dichloro(1,3-bis-(2,6-diisopentylphenyl)imidazolylidinium)(3-chloro-pyridine); cesium fluoride In 1,4-dioxane at 20 - 80℃; for 16h; Stille-Migita cross-coupling; Molecular sieve; Inert atmosphere;99%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

ethyl acetoacetate
141-97-9

ethyl acetoacetate

malononitrile
109-77-3

malononitrile

6-amino-4-(5-chlorothiophen-2-yl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile
1235990-64-3

6-amino-4-(5-chlorothiophen-2-yl)-2,4-dihydro-3,4-dimethylpyrano[2,3-c]pyrazole-5-carbonitrile

Conditions
ConditionsYield
With hydrazine hydrate; heptakis(6-amino-6-deoxy)-β-cyclodextrin at 20℃; for 0.0166667h; Neat (no solvent);99%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-chlorobenzaldehyde
104-88-1

4-chlorobenzaldehyde

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-chlorophenyl)prop-2-en-1-one
96583-49-2

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-chlorophenyl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;98%
With potassium hydroxide In methanol at 25℃; for 2h; Condensation;93%
With sodium hydroxide
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-dimethylamino-benzaldehyde
100-10-7

4-dimethylamino-benzaldehyde

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one
107058-33-3

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-[4-(dimethylamino)phenyl]prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;98%
With potassium hydroxide In ethanol; water at 20℃; for 48h; Claisen-Schmidt Condensation;79%
With sodium hydroxide; ethanol
4-Trifluoromethylbenzaldehyde
455-19-6

4-Trifluoromethylbenzaldehyde

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-[4-(trifluoromethyl)phenyl]prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;98%
With sodium hydroxide In ethanol; water at 20℃; for 1h; Inert atmosphere;18%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-ethylbenzylaldehyde
4748-78-1

4-ethylbenzylaldehyde

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-ethylphenyl)prop-2-en-1-one

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-ethylphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;98%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-bromo-benzaldehyde
1122-91-4

4-bromo-benzaldehyde

(2E)-3-(4-bromophenyl)-1-(4-chlorocyclopenta-1,3-dien-1-yl)prop-2-en-1-one

(2E)-3-(4-bromophenyl)-1-(4-chlorocyclopenta-1,3-dien-1-yl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;98%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

β-naphthaldehyde
66-99-9

β-naphthaldehyde

(2E)-1-(5-chlorothiophen-2-yl)-3-(naphthalen-2-yl)prop-2-en-1-one
1352445-09-0

(2E)-1-(5-chlorothiophen-2-yl)-3-(naphthalen-2-yl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In methanol at 20℃; for 24h; Aldol condensation;97%
With sodium hydroxide In methanol at 20℃;
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

potassium phenyltrifluoborate

potassium phenyltrifluoborate

5-phenyl-2-acetylthiophene
1665-41-4

5-phenyl-2-acetylthiophene

Conditions
ConditionsYield
With N-methyl-2-phenyl-3-(dicyclohexylphosphino)-1H-indole; palladium diacetate; potassium carbonate; triethylamine In water at 100℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere; Schlenk technique;97%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

1-(5-tosylthiophen-2-yl)ethan-1-one
1354558-40-9

1-(5-tosylthiophen-2-yl)ethan-1-one

Conditions
ConditionsYield
In dimethyl sulfoxide at 110℃; for 20h;96%
With quinoline; copper(l) chloride In 1-methyl-pyrrolidin-2-one at 140℃; for 0.1h; Microwave irradiation;85%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

oxalic acid diethyl ester
95-92-1

oxalic acid diethyl ester

ethyl 5-(5-chlorothiophen-2-yl)isoxazole-3-carboxylate
323594-72-5

ethyl 5-(5-chlorothiophen-2-yl)isoxazole-3-carboxylate

Conditions
ConditionsYield
With hydroxylamine hydrochloride96%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

phenylhydrazine
100-63-0

phenylhydrazine

C12H11ClN2S

C12H11ClN2S

Conditions
ConditionsYield
With acetic acid In ethanol at 20℃; for 33h;96%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

2-chloro-6-methoxyquinolin-3-carboxaldehyde
73568-29-3

2-chloro-6-methoxyquinolin-3-carboxaldehyde

(2E)-3-(2-chloro-6-methoxyquinolin-3-yl)-1-(5-chlorothien-2-yl)prop-2-en-1-one
1253278-27-1

(2E)-3-(2-chloro-6-methoxyquinolin-3-yl)-1-(5-chlorothien-2-yl)prop-2-en-1-one

Conditions
ConditionsYield
With sodium hydroxide In methanol; water at 20℃; for 2h; Claisen Schmidt condensation;95%
With sodium hydroxide In ethanol; water
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

phenylboronic acid
98-80-6

phenylboronic acid

5-phenyl-2-acetylthiophene
1665-41-4

5-phenyl-2-acetylthiophene

Conditions
ConditionsYield
With [Pd(3-[(2,6-diisopropylphenyl)-1-imidazolio]-2-quinoxalinide)(PPh3)Cl2]; potassium carbonate; triphenylphosphine In water at 100℃; for 3h; Suzuki-Miyaura Coupling;95%
With 4,5-dimethyl-3-(2-phenoxyphenyl)-1-(2,4,6-trimethylbenzyl)imidazolium chloride; palladium diacetate; caesium carbonate In 1,4-dioxane at 90℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere;81%
With potassium phosphate; C28H31ClN2Ni; triphenylphosphine In toluene; tert-butyl alcohol at 90℃; for 3.5h; Suzuki-Miyaura Coupling; Inert atmosphere; Sealed tube;47%
furfural
98-01-1

furfural

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

1-(5-chlorothiophen-2-yl)-3-(furan-2-yl)propenone

1-(5-chlorothiophen-2-yl)-3-(furan-2-yl)propenone

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 0℃; Claisen Schmidt condensation;94.21%
Stage #1: furfural With potassium hydroxide In methanol; water at 0℃; for 0.166667h;
Stage #2: 2-acetyl-5-chlorothiophene In methanol; water at 0℃; for 3h;
92%
With potassium hydroxide In methanol; water at 0℃;
furan-3-carboxaldehyde
498-60-2

furan-3-carboxaldehyde

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

1-(5-chlorothiophen-2-yl)-3-(furan-3-yl)propenone
1204578-99-3

1-(5-chlorothiophen-2-yl)-3-(furan-3-yl)propenone

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 0℃; Claisen Schmidt condensation;94.21%
With potassium hydroxide In methanol; water at 0℃;
thiophene-2-carbaldehyde
98-03-3

thiophene-2-carbaldehyde

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-Chloro-3-nitroaniline
635-22-3

4-Chloro-3-nitroaniline

C17H12Cl2N2O3S2
1037752-15-0

C17H12Cl2N2O3S2

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 0 - 50℃; Mannich reaction;94.2%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

(E)-1-(5-chlorothiophen-2-yl)ethan-1-one oxime
42520-87-6

(E)-1-(5-chlorothiophen-2-yl)ethan-1-one oxime

Conditions
ConditionsYield
With hydroxylamine hydrochloride; sodium acetate In ethanol at 20 - 80℃; for 16h;94%
With hydroxylamine
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 3h; Reflux;
With hydroxylamine hydrochloride; sodium acetate In ethanol; water for 3h; Reflux;
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-methoxy-benzaldehyde
123-11-5

4-methoxy-benzaldehyde

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

(2E)-1-(4-chlorocyclopenta-1,3-dien-1-yl)-3-(4-methoxyphenyl)prop-2-en-1-one

Conditions
ConditionsYield
With potassium hydroxide In ethanol; water at 20℃; for 4h;94%
With sodium hydroxide In methanol at 20℃;72%
With sodium hydroxide In methanol at 0 - 5℃;
With sodium hydroxide In methanol; water at 0 - 5℃; pH=10 - 11;
Thien-3-ylboronic acid
6165-69-1

Thien-3-ylboronic acid

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

1-([2,3′-bithiophen]-5-yl)ethanone
98946-35-1

1-([2,3′-bithiophen]-5-yl)ethanone

Conditions
ConditionsYield
With potassium phosphate; C46H52Cl3N3O2Pd In tetrahydrofuran; water at 60℃; for 4h; Suzuki-Miyaura Coupling;94%
With bis(η3-allyl-μ-chloropalladium(II)); 4,5-dimethyl-3-(2-phenoxyphenyl)-1-(2,4,6-trimethylbenzyl)imidazolium chloride; caesium carbonate In 1,4-dioxane at 100℃; for 18h; Suzuki-Miyaura Coupling; Inert atmosphere;74%
methanol
67-56-1

methanol

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

1-(5-methoxythiophen-2-yl)ethan-1-one
30009-72-4

1-(5-methoxythiophen-2-yl)ethan-1-one

Conditions
ConditionsYield
With t-BuBrettPhos; [(2-di-tert-butylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1’-biphenyl)-2-(2’-amino-1,1‘-biphenyl)]palladium(II) methanesulfonate; caesium carbonate In 1,4-dioxane at 50℃; for 20h; Sealed tube; Inert atmosphere;94%
With [(2-di-cyclohexylphosphino-3,6-dimethoxy-2’,4’,6’-triisopropyl-1,1‘-biphenyl)-2-(2‘-amino-1,1’-biphenyl)]palladium(II) methanesulfonate; caesium carbonate at 100℃; for 1h; Sealed tube; Microwave irradiation;33%
2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

(S)-1-(5-chlorothiophen-2-yl)ethan-1-ol

(S)-1-(5-chlorothiophen-2-yl)ethan-1-ol

Conditions
ConditionsYield
With triiron dodecarbonyl; C52H58N4P2; hydrogen; potassium hydroxide In methanol at 45℃; under 37503.8 Torr; for 10h; enantioselective reaction;94%
5-chloro-2-furaldehyde
21508-19-0

5-chloro-2-furaldehyde

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

3-(5-chlorofuran-2-yl)-1-(5-chlorothiophen-2-yl)-propenone
1204579-00-9

3-(5-chlorofuran-2-yl)-1-(5-chlorothiophen-2-yl)-propenone

Conditions
ConditionsYield
With potassium hydroxide In methanol; water at 0℃; Claisen Schmidt condensation;93.99%
furfural
98-01-1

furfural

2-acetyl-5-chlorothiophene
6310-09-4

2-acetyl-5-chlorothiophene

4-nitro-aniline
100-01-6

4-nitro-aniline

C17H13ClN2O4S
1037752-12-7

C17H13ClN2O4S

Conditions
ConditionsYield
With hydrogenchloride In ethanol at 0 - 50℃; Mannich reaction;93.2%

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