1070715-07-9

Upstream product

• 4397-53-9 p-benzyloxybenzaldehyde 
• 65490-09-7 2'-hydroxy-4',6'-bis(methoxymethoxy)acetophenone 
• 480-66-0 2,4,6-trihydroxyacetophenone 

Downstream Products

• 345891-63-6 rac-2-[4-(benzyloxy)phenyl]-5,7-dihydroxychroman-4-one 
• 948029-00-3 C₁₇H₁₄O₇ 
• 28116-98-5 rac-5,7-dihydroxy-2-[4-(3-methylbut-2-enyloxy)phenyl]chroman-4-one 
• 39953-45-2 Selinondiacetat 
• 517892-90-9 (±)-5,7-diacetoxy-4'-hydroxyflavan-4-one 
• 517892-89-6 acetic acid 7-acetoxy-2-(4-benzyloxy-phenyl)-4-oxo-chroman-5-yl ester 

Relevant academic research and scientific papers

A simple synthesis of selinone, an antifungal component of Monotes engleri

A new synthesis of racemic 5,7-dihydroxy-2-[4-(3-methyl-but-2-enyloxy)-phenyl]chroman-4-one (selinone) (rac-1a) isolated from Monotes engleri GILG was accomplished by two routes starting from MOM-protected phloracetophenone (2).

Synthesis and Biological Evaluation of 2,4,6-Trihydroxychalcone Derivatives as Novel Protein Tyrosine Phosphatase 1B Inhibitors

A series of 2,4,6-trihydroxychalcone derivatives were synthesized and identified as reversible and competitive protein tyrosine phosphatase (PTP) 1B inhibitors with IC50 values in the micromolar range. Compound 4a had the greatest in vitro inhibition activity against PTP1B (IC50=0.27± 0.01μm) and the best selectivity (6.9-fold) for PTP1B relative to T-cell protein tyrosine phosphatases. The compounds identified herein provide a foundation on which to design specific inhibitors of PTP1B and other PTPs.

Composition for treating cancer cells and synthetic method for the same

A pharmaceutical composition having a cytotoxic effect to a cancer cell and a method for the same are provided. The pharmaceutical composition comprises a flavonoid compound having at least one of the following formulas: and wherein B ring is a 4-oxo-cycl

First total synthesis of protoapigenone and its analogues as potent cytotoxic agents

Protoapigenone (1), isolated from Thelypteris torresiana, previously showed significant cytotoxic activity against five human cancer cell lines. In a continued structure-activity relationship study, the first total synthesis and modification of 1 were ach

Synthesis and evaluation of antiplatelet activity of trihydroxychalcone derivatives

In an effort to develop potent antiplatelet agents, a series of trihydroxychalcones was synthesized and screened in vitro for their inhibitory effects on washed rabbit platelet aggregation induced by arachidonic acid (100 μM) and collagen (10 μg/ml). Of five compounds with potent inhibitory effects on arachidonic acid- and collagen-induced platelet aggregation, compound 4e was found to be the most potent. The structure-activity relationships suggested that antiplatelet activity was governed to a greater extent by the substituent on B ring of the chalcone template, and most of the active compounds had methoxy or dimethoxy groups on B ring.