1070767-69-9Relevant academic research and scientific papers
Hf(OTf)4 as a highly potent catalyst for the synthesis of Mannich bases under solvent-free conditions
Gong, Shan-Shan,Han, Shuai-Bo,Liu, Rong,Peng, Xiao-Chong,Sun, Qi,Wei, Jing-Ying
, (2020/01/28)
Hf(OTf)4 was identified as a highly potent catalyst (0.1–0.5 mol%) for three-component Mannich reaction under solvent-free conditions. Hf(OTf)4-catalyzed Mannich reaction exhibited excellent regioselectivity and diastereoselectivity when alkyl ketones were employed as substrates. 1H NMR tracing of the H/D exchange reaction of ketones in MeOH-d4 indicated that Hf(OTf)4 could significantly promote the keto-enol tautomerization, thereby contributing to the acceleration of reaction rate.
Germanium(II)-mediated reductive Mannich-type reaction of α-bromoketones to N-alkylimines
Tanaka, Shin-Ya,Tagashira, Nobuo,Chiba, Kouji,Yasuda, Makoto,Baba, Akio
supporting information; experimental part, p. 6620 - 6623 (2009/03/12)
(Chemical Equation Presented) A versatile metal: Germanium was effectively used in a novel and efficient method for the Mannich-type reaction between α-bromoketones and simple N-alkyl imines (see scheme). Germanium(II) acts as a reducing agent, forming a
