1070872-75-1

Basic information

• Product Name: (-)-(4R,5R)-5-(3,5-difluoro-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide
• Synonyms: (-)-(4R,5R)-5-(3,5-difluoro-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide
• CAS NO: 1070872-75-1
• Molecular Weight: 313.301
• Mol File: 1070872-75-1.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: (-)-(4R,5R)-5-(3,5-difluoro-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(4R,5R)-5-(3,5-difluoro-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide(1070872-75-1)
• EPA Substance Registry System: (-)-(4R,5R)-5-(3,5-difluoro-benzoyl)-2,2-dimethyl-[1,3]dioxolane-4-carboxylic acid dimethylamide(1070872-75-1)

Safety Data

• Hazardous Substances Data: 1070872-75-1(Hazardous Substances Data)

Upstream product

• 62351-47-7 3,5-difluorophenylmagnesium bromide 
• 63126-29-4 (4R,5R)-2,2,N,N,N',N'-hexamethyl-1,3-dioxolane-4,5-dicarboxamide 

Relevant articles and documents

Enantiopure quaternary α-trifluoromethyl-α-alkoxyaldehydes from L-tartaric acid derived ketoamides

(Chemical Equation Presented) The diastereoselective nucleophilic trifluoromethylation of a range of ketoamides derived from L-tartaric acid has been studied. TMSCF3 in the presence of a catalytic amount of K 2CO3 in DMF has been identified as the conditions leading to the highest diastereoselectivities. A sequential one-pot reaction trifluoromethylation-etherification of the trifluoromethylcarbinol has been developed. Only one further one-pot reaction, ketal hydrolysis-oxidative cleavage, led to the final α-trifluoromethylated α-alkoxy-aldehydes. This procedure was applied to the preparation of a series of enantiopure aryl, heteroaryl, and alkyl α-trifluoromethyl-α-alkoxyaldehydes.