1070879-26-3Relevant articles and documents
Catalytic Enantioselective Methylene C(sp3)?H Amidation of 8-Alkylquinolines Using a Cp*RhIII/Chiral Carboxylic Acid System
Fukagawa, Seiya,Kojima, Masahiro,Yoshino, Tatsuhiko,Matsunaga, Shigeki
, p. 18154 - 18158 (2019)
Catalytic enantioselective directed methylene C(sp3)?H amidation reactions of 8-alkylquinolines using a Cp*RhIII/chiral carboxylic acid (CCA) hybrid catalytic system are described. A binaphthyl-based chiral carboxylic acid efficiently differentiates between the enantiotopic methylene C?H bonds, which leads to the formation of C?N bonds with good enantioselectivity.
PYRANOPYRAZOLE AND PYRAZOLOPYRIDINE IMMUNOMODULATORS FOR TREATMENT OF AUTOIMMUNE DISEASES
-
, (2019/06/17)
Pyranoyrazoles and pyrazolopyridines of formula I or formula II are disclosed: (I), (II) These compounds inhibit Coagulation Factor Xlla in the presence of thrombin and other coagulation factors. They are useful to treat autoimmune diseases.