71083-08-4

Upstream product

• 578-54-1 ortho-ethylaniline 
• 87-13-8 diethyl 2-ethoxymethylenemalonate 

Downstream Products

• 170648-67-6 8-ethyl-4(1H)-quinolinone-3-carboxylic acid 
• 1070879-26-3 4-bromo-8-ethylquinoline 
• 113515-72-3 ethyl 4-chloro-8-ethylquinoline-3-carboxylate 
• 206258-81-3 4-[benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-ethyl-quinoline-3-carboxylic acid 
• 206258-80-2 4-[benzyl-(4-methoxy-benzenesulfonyl)-amino]-8-ethyl-quinoline-3-carboxylic acid ethyl ester 

Relevant academic research and scientific papers

Synthesis and SAR of bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors

Potent and selective bicyclic heteroaryl hydroxamic acid MMP and TACE inhibitors were synthesized by a novel convergent route. Selectivity and efficacy versus MMPs and TACE could be controlled by appropriate substitution on the scaffolds and by variation of the P1′ group. Select compounds were found to be effective in in vivo models of arthritis.

Quinoline amides

Compounds of the formula: (wherein Ra represents an optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, cycloalkylalkyl, aryl, aralkyl or heteroaryl group; Rb and Rc, which may be the same or different, each represents hydrogen or an optionally substituted alkyl, cyclo- alkyl, cycloalkylalkyl, alkenyl, alkynyl, phenyl or benzyl group, or Rb and Rc together with the nitrogen atom therebetween represent a saturated nitrogen containing heterocyclic ring; and Rd represents a hydrogen atom or an alkyl or alkanoyl group) and the salts thereof are useful as agents for binding to benzodiazepine receptors, and especially possess anxiolytic activity.