1070908-85-8Relevant academic research and scientific papers
UnyLinker dimer impurity characterization and process improvement
Brooks, Joshua L.,Olsen, Phil,Chen, Lijian,Rodriguez, Andrew A.
, p. 1050 - 1052 (2017)
Herein, we describe the isolation and characterization of a UnyLinker dimer which, if left uncontrolled, can become incorporated in oligonucleotide products. The dimer is formed as a result of an unusual intermolecular osmium-catalyzed etherification. We
Convenient large-scale synthesis of universal solid support
Ravikumar, Vasulinga T.,Kumar, R. Krishna,Zhu, Xuefeng
, p. 2269 - 2274 (2006)
A simple, convenient large-scale synthesis of a universal solid support useful for the synthesis of oligonucleotides is described. Copyright Taylor & Francis Group, LLC.
UnyLinker: An efficient and scaleable synthesis of oligonucleotides utilizing a universal linker molecule: A novel approach to enhance the purity of drugs
Ravikumar, Vasulinga T.,Kumar, R. Krishna,Olsen, Phil,Moore, Max N.,Carty, Recaldo L.,Andrade, Mark,Gorman, Dennis,Zhu, Xuefeng,Cedillo, Isaiah,Wang, Zhiwei,Mendez, Lucio,Scozzari, Anthony N.,Aguirre, Gerardo,Somanathan, Ratnasamy,Bernees, Sylvain
, p. 399 - 410 (2008)
A novel universal linker (UnyLinker) molecule which has a conformationally rigid and chemically stable bridge head ring oxygen atom carrying a conventional 4,4-dimethoxytrityl (DMT) and succinyl groups locked in a syn orientation has been developed to car
Universal building blocks and support media for synthesis of oligonucleotides and their analogs
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Page 26, (2008/06/13)
Compounds for the synthesis of oligomeric compounds, particularly oligonucleotides and chemically modified oligonucleotide analogs, are provided. In addition, methods for functionalization of a support medium with a first monomeric subunit and methods for the synthesis of oligomeric compounds utilizing the novel compounds bound to support media are provided.
