107097-80-3 Usage
Description
Loxiglumide is a cholecystokinin type 1 (CCK1) receptor antagonist, which is a chemical compound that specifically targets and blocks the CCK1 receptor. It is known for its ability to suppress cholecystokinin-induced proliferation of acinar cells and inhibit pancreatic secretion of digestive enzymes. Loxiglumide has demonstrated activity in vivo, making it a potential candidate for various therapeutic applications.
Uses
Used in Pharmaceutical Industry:
Loxiglumide is used as a therapeutic agent for the treatment of pancreatic diseases, particularly those involving the overproduction of digestive enzymes and the proliferation of acinar cells. Its ability to inhibit pancreatic secretion and suppress acinar cell proliferation makes it a promising option for managing conditions such as chronic pancreatitis.
Used in Research Applications:
Loxiglumide is also used as a research tool in the study of cholecystokinin and its role in various physiological processes. As a CCK1 receptor antagonist, it can help researchers understand the specific functions of the CCK1 receptor and its involvement in pancreatic enzyme secretion, cell proliferation, and other related pathways.
Used in Drug Development:
In the field of drug development, Loxiglumide serves as a lead compound for the development of new medications targeting the CCK1 receptor. Its antagonistic properties can be leveraged to create more potent and selective drugs for the treatment of pancreatic disorders and potentially other conditions related to cholecystokinin signaling.
Biochem/physiol Actions
Loxiglumide is a small-molecule antagonist of the cholecystokinin receptor CCKA. Loxiglumide inhibits pancreatic secretion of digestive enzymes, and also blocks CCK-induced gastric secretions and emptying.
Safety Profile
A poison by
intravenous. Moderately toxic by ingestion,
intraperitoneal, and subcutaneous routes.
When heated to decomposition it emits
toxic vapors of NOx and Cl-.
Check Digit Verification of cas no
The CAS Registry Mumber 107097-80-3 includes 9 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 6 digits, 1,0,7,0,9 and 7 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 107097-80:
(8*1)+(7*0)+(6*7)+(5*0)+(4*9)+(3*7)+(2*8)+(1*0)=123
123 % 10 = 3
So 107097-80-3 is a valid CAS Registry Number.
InChI:InChI=1/C21H30Cl2N2O5/c1-3-4-5-11-25(12-6-13-30-2)21(29)18(9-10-19(26)27)24-20(28)15-7-8-16(22)17(23)14-15/h7-8,14,18H,3-6,9-13H2,1-2H3,(H,24,28)(H,26,27)
