1070978-49-2Relevant academic research and scientific papers
UREYLENE DERIVATIVES
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, (2008/12/04)
The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.
Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers
Drewe, William C.,Neidle, Stephen
supporting information; experimental part, p. 5295 - 5297 (2009/03/11)
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines. The Royal Society of Chemistry.
