1070978-84-5Relevant articles and documents
Structure-based design of selective high-affinity telomeric quadruplex-binding ligands
Lombardo, Caterina Maria,Martinez, Iria Sanchez,Haider, Shozeb,Gabelica, Valerie,De Pauw, Edwin,Moses, John E.,Neidle, Stephen
, p. 9116 - 9118 (2011/02/23)
A library of triazole-based telomeric quadruplex-selective ligands has been developed that mimic an established family of tri-substituted acridine-based ligands, using crystal structure data as a starting-point for computer-based design. Binding affinities, estimated by electrospray mass spectrometry, are in accord with the design concept.
UREYLENE DERIVATIVES
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, (2008/12/04)
The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.
Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers
Drewe, William C.,Neidle, Stephen
supporting information; experimental part, p. 5295 - 5297 (2009/03/11)
A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines. The Royal Society of Chemistry.
