1070979-25-7

Upstream product

• 52670-38-9 2-ethynylaniline 
• 530-62-1 1,1'-carbonyldiimidazole 

Downstream Products

• 1070978-51-6 1,3-bis-(2-(1-(4-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 
• 1070978-52-7 1,3-bis-(2-(1-(3-(4-(pyrrolidin-1-yl)butanamido)phenyl)-1H-1,2,3-triazol-4-yl)phenyl)urea 

Relevant academic research and scientific papers

Click chemistry assembly of G-quadruplex ligands incorporating a diarylurea scaffold and triazole linkers

A series of diarylurea ligands were designed to interact selectively with G-quadruplexes and were synthesised using copper(I) catalysed 'click' chemistry to incorporate the 1,4-substituted 1,2,3-triazole ring into the core of the ligands; the optimal ligands demonstrate a high degree of selective telomeric G-quadruplex stabilisation and are not cytotoxic in several cancer cell lines. The Royal Society of Chemistry.

UREYLENE DERIVATIVES

The invention concerns compounds of Formula (I) or a salt, solvate or pro-drug thereof. The compounds may be used in therapy, particularly anti-cancer therapy.