107126-27-2Relevant academic research and scientific papers
ONE-FLASK SYNTHESIS OF 4-(BIS(METHYLTHIO))METHYLENE-2-PHENYL-5-OXO-4,5-DIHYDRO-1,3-OXAZOLE AND ITS AMINOLYSES
Ashare, Ram,Roy, Jalpana,Mukerjee, Arya K.
, p. 1325 - 1329 (2007/10/02)
Cyclization of hippuric acid with ethyl chloroformate and triethylamine in benzene and subsequent triethylamine-mediated condensation with carbon disulphide and S-methylation afford the title compound which undergoes 1,5-bond cleavage on heating with molar proportion of a primary amine in the presence of glacial acetic acid, the ketenethioacetal moiety remaining intact.On increasing the proportion of the amine and heating the mixture for a longer period, the corresponding N,N'-disubstituted benzoylaminomalondiamides are obtained.
