1071435-62-5

Basic information

• Product Name: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine
• Synonyms: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine;(1S)-1-[6-(TRIFLUOROMETHYL)(3-PYRIDYL)]ETHYLAMINE
• CAS NO: 1071435-62-5
• Molecular Weight: 190.168
• Mol File: 1071435-62-5.mol

Chemical Properties

• CAS DataBase Reference: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine(1071435-62-5)
• EPA Substance Registry System: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine(1071435-62-5)

Safety Data

• Hazardous Substances Data: 1071435-62-5(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Industry:
(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine is used as a building block for the synthesis of various pharmaceutical compounds due to its unique structure and properties. The presence of the trifluoromethyl group and the amine functional group allows for the creation of new molecules with potential therapeutic applications.
Used in Agrochemical Industry:
(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine is used as a precursor in the development of agrochemicals, such as pesticides and herbicides. (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine's electron withdrawing properties and stereochemistry can be exploited to design molecules with enhanced biological activity and selectivity, leading to more effective and targeted agrochemical products.
Used in Chemical Research:
(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine serves as a valuable research tool in the field of organic chemistry. Its unique structure and properties make it an interesting subject for studying reaction mechanisms, exploring new synthetic routes, and understanding the relationship between molecular structure and biological activity.
Used in Material Science:
(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine's electron withdrawing trifluoromethyl group and amine functional group may also find applications in the development of new materials with specific properties, such as improved conductivity, stability, or reactivity. This can be particularly useful in the fields of electronics, energy storage, and advanced materials.

Upstream product

• 3938-96-3 ethyl 2-methoxyacetate 
• 886364-82-5 (±)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine 
• 216431-85-5 6-(trifluoromethyl)nicotinonitrile 
• 416852-53-4 N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide 
• 358780-14-0 1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one 
• 358780-13-9 6-(trifluoromethyl)nicotinoyl chloride 
• 1071435-65-8 (R)-2-Methyl-N-((S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)propane-2-sulfinamide 

Relevant articles and documents

Asymmetric Biocatalytic Synthesis of Fluorinated Pyridines through Transesterification or Transamination: Computational Insights into the Reactivity of Transaminases

The synthesis of a family of pyridines bearing a fluorinated substituent on the aromatic ring has been carried out through two independent and highly stereoselective chemoenzymatic strategies. Short chemical synthetic routes toward fluorinated racemic amines and prochiral ketones have been developed, which served as substrates to explore the suitability of lipases and transaminases in asymmetric biotransformations. The lipase-catalyzed kinetic resolution via acylation of racemic amines proceeded smoothly giving conversions close to 50% and excellent enantioselectivities. Alternatively, the biotransamination of the corresponding prochiral ketones was investigated giving access to both optically pure amine enantiomers using transaminases with complementary selectivity. High to quantitative conversion values were achieved, which allowed the isolation of the amines in moderate to high yields (40–88%). A deeper understanding of the latter process was enabled by performing theoretical calculations on thermodynamic and mechanistic aspects. Calculations showed that the biotransamination reactions are highly favoured by the presence of fluorine atoms and the pyridine ring. (Figure presented.).

N-formamido pyrazoline derivative serving as P2X3 receptor antagonist and application thereof

The invention discloses an N-formamido pyrazoline derivative, a compound represented by a general formula (I) or an enantiomer, a diastereoisomer, an epimer, a racemate or pharmaceutically acceptablesalt thereof. The compound is an antagonist of a ligand gated non-selective cationic channel receptor subtype P2X3, and can be used for treating or preventing various diseases mediated by a P2X3 receptor.

PYRID-2-YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF

Fused heterocyclic compounds are provided according to formula 1a or 1b: where R1, R2, and R3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

2-Cyanophenyl fused heterocyclic compounds, and compositions and uses thereof

Fused heterocyclic compounds are provided according to formula 1: where R1, R2, R3, and m are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.