(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine

Base Information

• Chemical Name: (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine
• CAS No.: 1071435-62-5
• Molecular Formula: C₈H₉F₃N₂
• Molecular Weight: 190.168
• Mol file: 1071435-62-5.mol

Synonyms:(S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine;(1S)-1-[6-(TRIFLUOROMETHYL)(3-PYRIDYL)]ETHYLAMINE

Chemical Property of (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine

There total 8 articles about (S)-1-(6-(Trifluoromethyl)pyridin-3-yl)ethanamine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

(R)-2-Methyl-N-((S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)propane-2-sulfinamide (1071435-65-8) → (S)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine (1071435-62-5,886364-82-5)

Guidance literature:

(R)-2-Methyl-N-((S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)propane-2-sulfinamide; With hydrogenchloride; In 1,4-dioxane; water; at 20 ℃; for 2h;

With sodium hydroxide; In water; pH=12;

Reference yield: 36.0%

ethyl 2-methoxyacetate (3938-96-3) + (±)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine (886364-82-5) → (S)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine (1071435-62-5,886364-82-5) + C11H13F3N2O2

Guidance literature:

With Candida antarctica Lipase type B; In tetrahydrofuran; at 30 ℃; for 3h; enantioselective reaction; Catalytic behavior; Inert atmosphere; Resolution of racemate; Enzymatic reaction;

DOI:10.1002/adsc.201600835

Reference yield:

6-(trifluoromethyl)nicotinoyl chloride (358780-13-9) → (S)-1-[(6-trifluoromethyl)pyridine-3-yl]ethan-1-amine (1071435-62-5,886364-82-5)

Guidance literature:

Multi-step reaction with 4 steps

1.1: pyridine / dichloromethane / 20 °C

1.2: 1 h

2.1: tetrahydrofuran; toluene / 0 °C / Inert atmosphere

3.1: titanium(IV) tetraethanolate / tetrahydrofuran / Inert atmosphere; Reflux

3.2: -50 - 20 °C

3.3: 0 °C

4.1: hydrogenchloride / 1,4-dioxane; water / 2 h / 20 °C

4.2: pH 12

With pyridine; hydrogenchloride; titanium(IV) tetraethanolate; In tetrahydrofuran; 1,4-dioxane; dichloromethane; water; toluene;

upstream raw materials:

(R)-2-Methyl-N-((S)-1-(6-(trifluoromethyl)pyridin-3-yl)ethyl)propane-2-sulfinamide

6-(trifluoromethyl)nicotinoyl chloride

1-[(6-trifluoromethyl)-pyridine-3-yl]ethan-1-one

N-methoxy-N-methyl-6-(trifluoromethyl)pyridine-3-carboxamide