107147-60-4

Basic information

• Product Name: 4-Morpholin-4-yl-benzenethiol
• Synonyms: 4-Morpholin-4-yl-benzenethiol
• CAS NO: 107147-60-4
• Molecular Formula: C₁₀H₁₃NOS
• Molecular Weight: 195.28
• Product Categories: pharmacetical
• Mol File: 107147-60-4.mol
• Article Data: 6

Chemical Properties

• Boiling Point: 351.9°Cat760mmHg
• Flash Point: 166.6°C
• Appearance: /
• Density: 1.18g/cm³
• Vapor Pressure: 0mmHg at 25°C
• Refractive Index: 1.596
• CAS DataBase Reference: 4-Morpholin-4-yl-benzenethiol(CAS DataBase Reference)
• NIST Chemistry Reference: 4-Morpholin-4-yl-benzenethiol(107147-60-4)
• EPA Substance Registry System: 4-Morpholin-4-yl-benzenethiol(107147-60-4)

Safety Data

• Hazardous Substances Data: 107147-60-4(Hazardous Substances Data)

Usage

InChI:InChI=1/C10H13NOS/c13-10-3-1-9(2-4-10)11-5-7-12-8-6-11/h1-4,13H,5-8H2

Upstream product

• 10389-51-2 1-morpholino-4-nitrobenzene 
• 589-87-7 1,4-bromoiodobenzene 
• 62237-50-7 2-(4-pyridinyl)ethyl-4'-bromophenyl sulfide 
• 881664-18-2 4-[4-(2-(pyridin-4-yl)ethylsulfanyl)phenyl]morpholine 
• 2524-67-6 4-morpholino-4-yl-phenylamine 

Downstream Products

• 111400-43-2 2-(4-morpholinophenylthiomethyl)benzoic acid 
• 568577-88-8 4-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)phenyl]morpholine 
• 106365-92-8 4-[4-(2,4-Dinitro-phenylsulfanyl)-phenyl]-morpholine 
• 111400-27-2 (2-(4-morpholinophenylthio)phenyl)acetic acid 
• 106365-98-4 2-(4-morpholinophenylthio)benzoic acid 

Relevant articles and documents

Potent and Specific Inhibition of NTCP-Mediated HBV/HDV Infection and Substrate Transporting by a Novel, Oral-Available Cyclosporine A Analogue

Analogues of the natural product cyclosporine A (CsA) were developed and assessed as antivirals against infection of hepatitis B virus (HBV) and its satellite hepatitis D virus (HDV). An analogue termed 27A exhibits potent inhibition of HBV/HDV infection by specifically blocking viral engagement to its cellular receptor NTCP, while it lacks immunosuppressive activity found in natural CsA. Intraperitoneal injection or oral intake of 27A protects HDV-susceptible mouse model from HDV infection. 27A serves as a promising lead for the development of novel anti-HDV/HBV agents.

Practical thiol surrogates and protective groups for arylthiols for Suzuki-Miyaura conditions

We have developed practical thiol surrogates and arylthiol protective groups for the Suzuki-Miyaura reaction. 2-Ethylhexyl-3-mercaptopropionate and 4-(2′-mercaptoethyl)pyridine were shown to be not only good thiol surrogates but also good protective groups for thiol. We have demonstrated toleration of these protective groups under aqueous Suzuki-Miyaura conditions.

Linear Free Energy Relationship Studies of 5-Substituted 2,4-Dioxopyrimidine Nucleosides

The development of a direct and efficient palladium(0)-catalyzed biaryl coupling reaction permitted the synthesis of a series of N1-substituted 5-aryl-2,4-dioxopyrimidines.The physical and spectral properties of these compounds were determined and correlated by various linear free energy relationships.The relationships between the physical and spectral data with Hammett ? constants proved useful in analyzing the electron distribution of the heterocycle.Although a significant degree of orbital overlap and interaction between the substituents and the pyrimidine ring was observed, it is doubtful that the interactions are comparable to those of a benzene ring system.