107166-81-4

Upstream product

• 103-72-0 phenyl isothiocyanate 
• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 
• 107166-86-9 N-Amino-N-ethoxycarbonylmethyl-N-phenyl-thiourea 

Downstream Products

• 130179-62-3 2-[4-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130214-96-9 2-[4-(4-Chloro-phenyl)-3-(4-chloro-phenylamino)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130214-95-8 2-[4-(4-Fluoro-phenyl)-3-(4-fluoro-phenylamino)-5-oxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130179-61-2 2-(5-Oxo-4-p-tolyl-3-p-tolylamino-4,5-dihydro-[1,2,4]triazol-1-yl)-N-phenyl-acetamide 
• 130179-60-1 2-(5-Oxo-4-phenyl-3-phenylamino-4,5-dihydro-[1,2,4]triazol-1-yl)-N-phenyl-acetamide 
• 130179-48-5 2,9-bis(propylamino)-7-oxo-6-phenyl-5-thioxo-3H-imidazo<1,5-d><1,3,4>oxadiazine 
• 130179-54-3 {5-tert-Butylamino-2-[(E)-phenylimino]-[1,3,4]thiadiazol-3-yl}-acetic acid methyl ester 
• 126177-84-2 5-(4-Bromophenyl)-3-methoxycarbonylmethyl-2-phenylimino-3,6-dihydro-2H-1,3,4-thiadiazine 
• 126177-87-5 3,5-Bis(methylthio)-4-(4-chlorophenyl)-1-phenylaminocarbonylmethyl-4,5-dihydro-1H-1,2,4-triazol-4-ium iodide 
• 126177-86-4 3,5-Bis(methylthio)-4-(4-bromophenyl)-1-phenylaminocarbonylmethyl-3,4-dihydro-1H-1,2,4-triazol-4-ium iodide 
• 126177-74-0 2-[4-(4-Bromo-phenyl)-3-mercapto-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide; compound with triethyl-amine 
• 126177-79-5 2-[4-(4-Chloro-phenyl)-3-mercapto-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide; compound with triethyl-amine 

Relevant academic research and scientific papers

Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities

Twenty-three new 7-halo-4-hydroxy-2H(or alkyl)-N-(3-aralkyl-2-thio-l-hydantoinyl)-2H- 1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2H(or alkyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 1-amino-2-thio-3-aralkyl-imidazolidine-4-one. The analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing syndrome and carrageenan rat paw edema tests. In analgesic activities most compounds exhibited higher activities than acetylsalicylic acid, but in antiinflammatory activities most compounds except compounds 24, 36, 39 showed lower activities than indometacin.

Synthesis and immunomodulating activity of 1-amino-2-thiohydantoin derivatives

1-Amino-2-thiohydantoin derivatives have been synthesized. Immunomodulating and anticancer activities have been studied. Their activity on the immune system is complex, being either immunodepressive or immunostimulatory according to the doses, or mainly immunostimulatory. These compounds were devoid of any anticancer activity.