107166-81-4

Upstream product

• 6945-92-2 2-hydrazinyl acetic acid ethyl ester hydrochloride 
• 103-72-0 phenyl isothiocyanate 
• 107166-86-9 N-Amino-N-ethoxycarbonylmethyl-N-phenyl-thiourea 

Downstream Products

• 146860-02-8 2-[(E)-4-Oxo-3-phenyl-2-thioxo-imidazolidin-1-ylimino]-propionic acid ethyl ester 
• 146860-01-7 [(E)-4-Oxo-3-phenyl-2-thioxo-imidazolidin-1-ylimino]-acetic acid ethyl ester 
• 130214-84-5 2-[4-(4-Methoxy-phenyl)-3-(4-methoxy-phenylamino)-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130179-56-5 N-Phenyl-2-(5-thioxo-4-p-tolyl-3-p-tolylamino-4,5-dihydro-[1,2,4]triazol-1-yl)-acetamide 
• 130179-59-8 2-[4-(4-Bromo-phenyl)-3-(4-bromo-phenylamino)-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130179-58-7 2-[4-(4-Chloro-phenyl)-3-(4-chloro-phenylamino)-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 130179-57-6 2-[4-(4-Fluoro-phenyl)-3-(4-fluoro-phenylamino)-5-thioxo-4,5-dihydro-[1,2,4]triazol-1-yl]-N-phenyl-acetamide 
• 107166-84-7 1-Diacetylamino-3-phenyl-2-thioxo-4-imidazolidinone 
• 126177-58-0 {5-(4-Nitro-phenyl)-2-[(Z)-phenylimino]-6H-[1,3,4]thiadiazin-3-yl}-acetic acid methyl ester; hydrobromide 
• 126177-59-1 {5-(4-Nitro-phenyl)-2-[(Z)-phenylimino]-6H-[1,3,4]thiadiazin-3-yl}-acetic acid ethyl ester; hydrobromide 
• 146860-00-6 1-benzylideneamino-3-phenyl-2-thiohydantoin 
• 142917-00-8 1-benzoylamino-3-phenyl-2-thiohydantoin 
• 146860-05-1 1-ureido-3-phenyl-2-thiohydantoin 
• 126177-68-2 1-thioureido-3-phenyl-2-thiohydantoin 

Relevant academic research and scientific papers

Some new 1,2-benzothiazine derivatives with analgesic and anti-inflammatory activities

Twenty-three new 7-halo-4-hydroxy-2H(or alkyl)-N-(3-aralkyl-2-thio-l-hydantoinyl)-2H- 1,2-benzothiazine-3-carboxamide 1,1-dioxide derivatives were synthesized through the condensation of 7-halo-4-hydroxy-2H(or alkyl)-1,2-benzothiazine-3-carboxylic acid methyl ester 1,1-dioxides with 1-amino-2-thio-3-aralkyl-imidazolidine-4-one. The analgesic and anti-inflammatory activities of the synthesized compounds were investigated by acetic acid-induced writhing syndrome and carrageenan rat paw edema tests. In analgesic activities most compounds exhibited higher activities than acetylsalicylic acid, but in antiinflammatory activities most compounds except compounds 24, 36, 39 showed lower activities than indometacin.

Synthesis and immunomodulating activity of 1-amino-2-thiohydantoin derivatives

1-Amino-2-thiohydantoin derivatives have been synthesized. Immunomodulating and anticancer activities have been studied. Their activity on the immune system is complex, being either immunodepressive or immunostimulatory according to the doses, or mainly immunostimulatory. These compounds were devoid of any anticancer activity.