107173-65-9

Upstream product

• 140-10-3 (E)-3-phenylacrylic acid 
• 147-85-3 L-proline 
• 102-92-1 cinnamoyl chloride 
• 102-92-1 Cinnamoyl chloride 

Downstream Products

• 57403-76-6 (R)-3-phenylheptanoic acid 
• 61999-35-7 (S)-(+)-3-phenylheptanoic acid 
• 107173-66-0 (S)-1-((R)-3-Phenyl-heptanoyl)-pyrrolidine-2-carboxylic acid 
• 188300-53-0 (S)-3-Phenyl-7,8,9,9a-tetrahydro-2H-pyrrolo[1,2-a][1,4]diazepine-1,5-dione 
• 188300-62-1 (S)-1-[(E)-(3-Phenyl-acryloyl)]-pyrrolidine-2-carboxylic acid amide 
• 188300-52-9 (S)-3-Phenyl-4-phenylselanyl-7,8,9,9a-tetrahydro-2H-pyrrolo[1,2-a][1,4]diazepine-1,5-dione 
• 188300-51-8 (3R,4R,9aS)-3-Phenyl-4-phenylselanyl-hexahydro-pyrrolo[1,2-a][1,4]diazepine-1,5-dione 
• 479692-10-9 (S)-4-Methyl-2-[((S)-1-{(2S,3R)-3-phenyl-1-[(E)-(3-phenyl-acryloyl)]-aziridine-2-carbonyl}-pyrrolidine-2-carbonyl)-amino]-pentanoic acid methyl ester 
• 330636-99-2 (S)-4-Methyl-2-[((2S,3R)-3-phenyl-1-{(S)-1-[(E)-(3-phenyl-acryloyl)]-pyrrolidine-2-carbonyl}-aziridine-2-carbonyl)-amino]-pentanoic acid methyl ester 
• 330637-00-8 (S)-4-Methyl-2-[(Z)-3-phenyl-2-({(S)-1-[(E)-(3-phenyl-acryloyl)]-pyrrolidine-2-carbonyl}-amino)-acryloylamino]-pentanoic acid methyl ester 
• 479692-14-3 (S)-4-Methyl-2-({(S)-1-[(4R,5S)-5-phenyl-2-((E)-styryl)-4,5-dihydro-oxazole-4-carbonyl]-pyrrolidine-2-carbonyl}-amino)-pentanoic acid methyl ester 
• 479692-07-4 (S)-2-{[(S)-1-((2R,3R)-3-Azido-2-hydroxy-3-phenyl-propionyl)-pyrrolidine-2-carbonyl]-amino}-4-methyl-pentanoic acid methyl ester 
• 479692-08-5 (S)-4-Methyl-2-{[(S)-1-((2S,3R)-3-phenyl-aziridine-2-carbonyl)-pyrrolidine-2-carbonyl]-amino}-pentanoic acid methyl ester 
• 479692-19-8 methyl N-(N-cinnamoyl-(L)-prolyl)-3-phenylaziridine-2-carboxylic acid 

Relevant academic research and scientific papers

Synthesis, physicochemical and quantum chemical studies on a new organic NLO crystal: Cinnamoylproline

Cinnamoylproline was synthesized and the crystal was grown from solution by the slow evaporation method. The crystal belongs to the trigonal crystal system with non-centrosymmetric space group P31. The calculated geometry and experimental geome

Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone

SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone were studied. This backbone has been developed in our group, and it is derived from a compound originally found by virtual screening. In addition, compounds with a smaller 3-phenylpropenoic acid tryptamide backbone were also included in the study. Binding modes for the new compounds and the previously reported compounds were analyzed with molecular modelling methods. The approach, which included a combination of molecular dynamics, molecular docking and cluster analysis, showed that certain docking poses were favourable despite the conformational variation in the target protein. The N-(3-phenylpropenoyl)-glycine tryptamide backbone is also a good backbone for SIRT2 inhibitors, and the series of compounds includes several potent SIRT2 inhibitors.

Novel asymmetric phenylselenium-induced lactamizations of olefinic amides: Stereoselective routes to α- and β-amino acids

Organoselenium-induced cyclofunctionalization of the (S)-N-(α,β-unsaturated) acylprolinamides 1, 7 and 14 has been found to produce the 7-membered bislactam products 2 and 15, or the 6-membered phenylselenolactam products 8 and 9 depending on the substitution pattern of the enone moiety of the starting material. The structural identities and stereochemistry of the cyclized products have been determined by X-ray diffraction, and the diastereoselectivity in the formation of the 7-membered ring bislactam product was found to be 91.6% de. The mechanism of the cyclolactamization is discussed.

A diastereoselective phenylselenium-induced lactamization of olefimic amides. A possible route to α- and β-amino acid derivatives

The organoselenium-induced cyclofunctionalization of (S)-N-(α,β-unsaturated-acyl)prolinamides was found to produce with a high degree of chirality transfer, 7- and 6-membered bislactam derivatives depending on the substitution pattern of the starting material.

Asymmetric Conjugate Addition of Organometallic Reagents in the Presence of Tertiary Amines to Chiral α,β-Unsaturated Amido Carboxylic Acids. Addition Order of Reagents as an Unprecedented Factor in the Determination of the Sence of Asymmetric Induction

Optically active 3-substituted carboxylic acids have been obtained in moderate enantiomeric excesses (e.e.) by asymmetric conjugate addition of alkyl-lithium, in the presence of tertiary amines, to chiral α,β-unsaturated amido carboxylic acids derived fro