1071781-15-1

Basic information

• Product Name: N-phenyl-2-[3-({3-[2-(anilinothiocarbonyl)hydrazino]-3-oxopropyl}anilino)propanoyl]-1-hydrazino-carbothioamide
• Synonyms: N-phenyl-2-[3-({3-[2-(anilinothiocarbonyl)hydrazino]-3-oxopropyl}anilino)propanoyl]-1-hydrazino-carbothioamide
• CAS NO: 1071781-15-1
• Molecular Weight: 535.694
• Mol File: 1071781-15-1.mol

Chemical Properties

• CAS DataBase Reference: N-phenyl-2-[3-({3-[2-(anilinothiocarbonyl)hydrazino]-3-oxopropyl}anilino)propanoyl]-1-hydrazino-carbothioamide(CAS DataBase Reference)
• NIST Chemistry Reference: N-phenyl-2-[3-({3-[2-(anilinothiocarbonyl)hydrazino]-3-oxopropyl}anilino)propanoyl]-1-hydrazino-carbothioamide(1071781-15-1)
• EPA Substance Registry System: N-phenyl-2-[3-({3-[2-(anilinothiocarbonyl)hydrazino]-3-oxopropyl}anilino)propanoyl]-1-hydrazino-carbothioamide(1071781-15-1)

Safety Data

• Hazardous Substances Data: 1071781-15-1(Hazardous Substances Data)

Upstream product

• 56329-74-9 3,3′-(phenylazanediyl)dipropanehydrazide 
• 103-72-0 phenyl isothiocyanate 

Relevant articles and documents

Synthesis and biological activity of 1,3,4-oxa(thia)diazole, 1,2,4-triazole-5-(thio)one and S-substituted derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid

Abstract: A series of novel derivatives of 3-((2-carboxyethyl)phenylamino)propanoic acid bearing two identical substituted 1,3,4-oxadiazole, 1,3,4-thiadiazole, or 1,2,4-triazole moieties were synthesized and their molecular structures were confirmed by IR, 1H, 13C NMR spectroscopy, and elemental analysis data. The synthesized compounds were screened for their reducing power, free radical scavenging, plant growth regulating, and antimicrobial properties. 5,5′-((Phenylazanediyl)bis(ethane-2,1-diyl))bis(4-phenyl-2,4-dihydro-3H-1,2,4-triazole-3-thione) showed excellent antioxidant activity, three times higher than that of the antibiotic control (cefazolin). 2,2′-((((Phenylazanediyl)bis(ethane-2,1-diyl))bis(4-phenyl-4H-1,2,4-triazole-5,3-diyl))bis(sulfanediyl))diacetate exhibited notable bactericidal activity against Pseudomonas aeruginosa with MBC and MIC values 7.3?μg/ml, whereas 12 compounds displayed significant fungicidal activity against Candida albicans with MIC value 3.9?μg/ml. Graphical Abstract: Synthesis of compounds 2–27. R: 2, 5, 7, 10, 13, 15-27 C6H5–; 3, 8, 11 4-Cl-C6H4–; 4, 9, 12 CH3–; 6, 14 2.6-(CH3)2-C6H3–; R′: 15 CH3CH2–; 16 (CH3)2CH–; 17 (CH3)2CHCH2–; 18 CH3CH2CH2CH2–; 19 (CH3)2CHCH2CH2–; 20 CH3CH2CH2CH2CH2–; 21 NH2COCH2–; 22 C6H5CH2–; 23 C6H5COCH2–; 24 4-ClC6H4COCH2–; 25 4-NO2C6H4COCH2–; 26 C2H5OCOCH2–.[Figure not available: see fulltext.]

Synthesis of azoles from 3-[(3-hydrazino-3-oxopropyl)anilino]-and 3-[(3-hydrazino-3-oxopropyl)-4-methylanilino]propane hydrazides

Condensation of 3-[(3-hydrazino-3-oxopropyl)anilino]-and 3-[(3-hydrazino-3-oxopropyl)-4-methylanilino]propane hydrazides with 2,4-pentanedione, phenyl isocyanate or phenyl isothiocyanate (with subsequent work up of the semicarbazides obtained by base), and carbon disulfide gave respectively: 1-(3,5-dimethyl-1H-1-pyrazolyl)-3-[3-(3,5-dimethyl-1H-1-pyrazolyl) -3-oxopropylanilino]-1-propanone, 3-(2-{[2-(5-oxo-4-phenyl-4,5-dihydro-1H-1,2,4- triazol-3-yl)ethyl]anilino}ethyl)-4-phenyl-4,5-dihydro-1H-1,2,4-triazol-5-one and its thio analog, and 5-(2-{[2-(2-thioxo-2,3-dihydro-1,3,4-oxadiazol-5-yl) ethyl]anilino}ethyl)-2,3-dihydro-1,3,4-oxadiazole-2(3H)-thione plus their methyl derivatives.