107196-98-5

Upstream product

• 1694-92-4 2-Nitrobenzenesulfonyl chloride 
• 609-36-9 rac-Pro-OH 
• 147-85-3 L-proline 

Downstream Products

• 107197-01-3 1-(2-Nitro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 72922-96-4 Trifluoro-methanesulfonate1-(2-nitro-benzenesulfonyl)-3,4-dihydro-2H-pyrrolium; 
• 72923-04-7 2-(2-nitrophenylsulphonylamino)pyrrolidine 

Relevant academic research and scientific papers

New antiprotozoal agents: Synthesis and biological evaluation of different 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives

In an endeavor to develop efficacious antiprotozoal agents 4-(7-chloroquinolin-4-yl) piperazin-1-yl)pyrrolidin-2-yl)methanone derivatives (5–14) were synthesized, characterized and biologically evaluated for antiprotozoal activity. The compounds were scre

Synthesis of the (E)-dehydrobutyrine-thiazoline-proline-leucine fragment of vioprolides B and D

A procedure is reported for the introduction of both the thiazoline and (E)-dehydrobutyrine components into a tetrapeptide-derived fragment of vioprolides B and D. The (E)-dehydrobutyrine is introduced first but, as the carbon-carbon double-bond of the dehydrobutyrine appeared incompatible with an adjacent thiol, the thiazoline was assembled by dehydration of a serine containing thioamide not by dehydration of a cysteinyl analogue.

PROCESS FOR THE REMOVAL OF NITROBENZENESULFONYL

A 2- or 4-nitrobenzenesulfonamide is allowed to react with an alkali metal alkoxide to remove a nitrobenzenesulfonyl group to thereby obtain an amine corresponding to the amide. Furthermore, a method for producing an amine derivative by allowing the resulting amine without isolation to react with an activated, substituted oxycarbonyl compound or an activated acyl compound is provided. According to this method, a corresponding free amine and its substituted derivative can be produced easily and industrially advantageously from the 2- or 4-nitrobenzenesulfonamide without using a thiol compound.

Synthesis of 1,2,4-Benzothiadiazines via Readily Generated Iminium Ions

A general method for the regiospecific synthesis of 1,2,4-benzothiadiazines, which are powerful diuretics and antihypertensive agents, has been developed.The N-arylsulphonylprolyl chlorides (5)-(7) reacted instantaneously with silver trifluoromethanesulphonate at room temperature to give the iminium salts (9)-(11) which provided the nitroamines (13)-(15) in quantitative yield.Reductive cyclisation of the nitroamines led to the tetrahydro-1H-pyrrolobenzothiadiazine 5,5-dioxide (17)-(20) in very good yields.No optimisation of yields was attempted. Efficient methods for the synthesis of some new substituted N-(nitrobenzenesulphonyl)-pyrrolidinecarboxulic acids (1)-(4), which were not readily available, are also described.