107197-05-7

Basic information

• Product Name: 2-(4-methoxy-2-nitrophenylsulphonylamino)pyrrolidine
• CAS NO: 107197-05-7
• Molecular Weight: 301.323
• Mol File: 107197-05-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 2-(4-methoxy-2-nitrophenylsulphonylamino)pyrrolidine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(4-methoxy-2-nitrophenylsulphonylamino)pyrrolidine(107197-05-7)
• EPA Substance Registry System: 2-(4-methoxy-2-nitrophenylsulphonylamino)pyrrolidine(107197-05-7)

Safety Data

• Hazardous Substances Data: 107197-05-7(Hazardous Substances Data)

Upstream product

• 107197-02-4 1-(4-Methoxy-2-nitro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride 
• 107196-99-6 N-(4-methoxy-2-nitrophenylsulphonyl)pyrrolidine-2-carboxylic acid 
• 18092-54-1 4-methoxy-2-nitrobenzenesulfonyl chloride 

Relevant articles and documents

Synthesis of 1,2,4-Benzothiadiazines via Readily Generated Iminium Ions

A general method for the regiospecific synthesis of 1,2,4-benzothiadiazines, which are powerful diuretics and antihypertensive agents, has been developed.The N-arylsulphonylprolyl chlorides (5)-(7) reacted instantaneously with silver trifluoromethanesulphonate at room temperature to give the iminium salts (9)-(11) which provided the nitroamines (13)-(15) in quantitative yield.Reductive cyclisation of the nitroamines led to the tetrahydro-1H-pyrrolobenzothiadiazine 5,5-dioxide (17)-(20) in very good yields.No optimisation of yields was attempted. Efficient methods for the synthesis of some new substituted N-(nitrobenzenesulphonyl)-pyrrolidinecarboxulic acids (1)-(4), which were not readily available, are also described.