18092-54-1

Basic information

• Product Name: 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE
• Synonyms: 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE;methoxynitrobenzenesulfonylchloride;4-methoxy-2-nitrobenzenesulphonyl chloride;4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE, 93+%;Einecs 241-996-9;4-Methoxy-2-nitrobenzene-1-sulfonyl chloride
• CAS NO: 18092-54-1
• Molecular Formula: C₇H₆ClNO₅S
• Molecular Weight: 251.64
• EINECS: 241-996-9
• Product Categories: Protection & Derivatization Reagents (for Synthesis);Synthetic Organic Chemistry
• Mol File: 18092-54-1.mol
• Article Data: 1

Chemical Properties

• Melting Point: 78°C
• Boiling Point: 416.2°Cat760mmHg
• Flash Point: 205.5°C
• Appearance: /
• Density: 1.553g/cm³
• Vapor Pressure: 3.91mmHg at 25°C
• Refractive Index: 1.479
• Storage Temp.: under inert gas (nitrogen or Argon) at 2-8°C
• CAS DataBase Reference: 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE(18092-54-1)
• EPA Substance Registry System: 4-METHOXY-2-NITROBENZENESULFONYL CHLORIDE(18092-54-1)

Safety Data

• Hazard Codes: C
• Statements: 34
• Safety Statements: 26-36/37/39-45
• RIDADR: 3261
• HazardClass: 8
• PackingGroup: III
• Hazardous Substances Data: 18092-54-1(Hazardous Substances Data)

Usage

General Description

4-Methoxy-2-nitrobenzenesulfonyl Chloride is a type of chemical compound, often used in synthetic organic chemistry. Its intricate name denotes the specific elements and structure it consists of: a benzene ring with a nitro group (NO2), a methoxy group (OCH3), and a sulfonyl chloride group (SO2Cl). This chemical is noted for its particular reactivity due to the presence of the sulfonyl chloride group, which makes it a good electrophile. Its characteristics and high reactivity make it useful in various chemical reactions and transformations as an intermediate. Extra precautions should be exercised during its handling due to its corrosive nature.

InChI:InChI=1/C6H12N2Si/c1-9(2,3)8-6-4-5-7-8/h4-6H,1-3H3

Upstream product

• 96-96-8 4-methoxy-2-nitroaniline 
• 119-81-3 4-methoxy-2-nitroacetanilide 
• 14371-84-7 4,4′-dimethoxy-2,2′-dinitro-diphenyl disulfide 

Downstream Products

• 81792-84-9 4-Methoxy-2-nitro-benzol-sulfonsaeure-⁽¹⁾-amid 
• 107197-05-7 2-(4-methoxy-2-nitrophenylsulphonylamino)pyrrolidine 
• 107197-02-4 1-(4-Methoxy-2-nitro-benzenesulfonyl)-pyrrolidine-2-carbonyl chloride 
• 1605280-01-0 3-benzyl-8-methoxy-1H-benzo[e]imidazo[1,2-b][1,2,4]thiadiazin-2(3H)-one-5,5-dioxide 
• 1370451-32-3 2-(4-methoxy-2-nitrophenylsulfonylamino)ethyl methanesulfonate 
• 89840-92-6 C₈H₁₀N₂O₅S 

Relevant articles and documents

Novel benzopyridothiadiazepines as potential active antitumor agents

The synthesis of novel thiadiazepine derivatives, that could be considered as constraint analogues of E-7010, are reported. These molecules were evaluated for their antiproliferative activity toward the murine L1210 leukemia cell line. Flow cytometric studies performed on L1210 cells with the most cytotoxic compounds showed an accumulation of the cells in the G2/M phases of the cell cycle with a significant percentage of tetraploid cells (8N DNA content). Submicromolar cytotoxicities were observed with compounds 2b, 4b, 4e, 4g, and 4i. Two of them, compounds 2b and 4b, were found to be potent inhibitors of tubulin polymerization with IC50 of respectively 3.8 and 2.4 μM compared to 2.4 μM for desoxypodophyllotoxin. A 4-methoxyphenylethyl substitution on the pyridinyl nitrogen of the benzopyridothiadiazepine was found to be essential for the antiproliferative activity. The in vitro activities of compounds 2b and 4b make benzopyridothiadiazepine dioxides a promising new class of tubulin binders which warrant further in vivo evaluation.