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1072027-36-1

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1072027-36-1 Usage

Description

4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is a chemical compound characterized by its unique molecular structure, which features a pyrrolo[2,3-d]pyrimidine core with a 4-Boc-1-piperazinyl substituent and a bromine atom at the 5th position. 4-(4-Boc-1-piperazinyl)-5-broMo-7H-pyrrolo[2,3-d]pyriMidine is of interest in the field of medicinal chemistry due to its potential applications in the development of therapeutic agents.

Uses

Used in Pharmaceutical Industry:
4-(4-Boc-1-piperazinyl)-5-bromo-7H-pyrrolo[2,3-d]pyrimidine is used as a reactant for the preparation of 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives. These derivatives are known to act as Akt inhibitors, which are important in the development of antiproliferative agents. Akt, also known as protein kinase B, plays a crucial role in cell survival, growth, and proliferation. Inhibiting Akt activity can lead to the suppression of tumor growth, making these derivatives potential candidates for cancer treatment.
The compound's use in the pharmaceutical industry is primarily focused on its role as a building block for the synthesis of Akt inhibitors. These inhibitors can be further optimized and developed into more potent and selective drugs for the treatment of various types of cancer. The antiproliferative effects of these derivatives make them valuable tools in the fight against cancer, as they can help to slow down or stop the uncontrolled growth of cancer cells.

Check Digit Verification of cas no

The CAS Registry Mumber 1072027-36-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,0,2 and 7 respectively; the second part has 2 digits, 3 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 1072027-36:
(9*1)+(8*0)+(7*7)+(6*2)+(5*0)+(4*2)+(3*7)+(2*3)+(1*6)=111
111 % 10 = 1
So 1072027-36-1 is a valid CAS Registry Number.

1072027-36-1SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name 2-Methyl-2-propanyl 4-(5-bromo-7H-pyrrolo[2,3-d]pyrimidin-4-yl)-1 -piperazinecarboxylate

1.2 Other means of identification

Product number -
Other names -

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
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More Details:1072027-36-1 SDS

1072027-36-1Relevant articles and documents

Structural optimization elaborates novel potent Akt inhibitors with promising anticancer activity

Liu, Yang,Yin, Yanzhen,Zhang, Zhen,Li, Carrie J.,Zhang, Hui,Zhang, Daoguang,Jiang, Changying,Nomie, Krystle,Zhang, Liang,Wang, Michael L.,Zhao, Guisen

, p. 543 - 551 (2017)

Targeting of Akt has been validated as a well rationalized approach to cancer treatment, and represents a promising therapeutic strategy for aggressive hematologic malignancies. We describe herein an exploration of novel Akt inhibitors for cancer therapy through structural optimization of previously described 4-(piperazin-1-yl)-7H-pyrrolo[2,3-d]pyrimidine derivatives. Our studies yielded a novel series of pyrrolopyrimidine based phenylpiperidine carboxamides capable of potent inhibition of Akt1. Notably, 10h exhibited robust antiproliferative effects in both mantle cell lymphoma cell lines and primary patient tumor cells. Low micromolar doses of 10h induced cell apoptosis and cell cycle arrest in G2/M phase, and significantly downregulated the phosphorylation of Akt downstream effectors GSK3β and S6 in Jeko-1 cells.

Extensive investigation of benzylic N-containing substituents on the pyrrolopyrimidine skeleton as Akt inhibitors with potent anticancer activity

Chen, Xin,Guo, Kaiwen,Liu, Yang,Ran, Fansheng,Zhang, Zhen,Zhao, Guisen

, (2020/03/03)

Continuous optimization of benzylic substituents on 1-(4-(7H-pyrrolo[2,3-d]pyrimidin-4-yl)piperazin-1-yl)-2-phenylethan-1-one structure as Akt inhibitors was described in this paper. Particularly, compounds 8 and 14g exhibited high enzymatic potency against all Akt isoforms and antiproliferative effects in mantle cell lymphoma cell lines, as well as favorable cytotoxicities in patient primary cancer cells. Low micromolar doses of both 8 and 14g dose-dependently induced cell apoptosis and G2/M cell cycle arrest, also suppressed the phosphorylation level of Akt downstream targets GSK3β and S6.

Substituted p-chlorophenyl acetylpiperazine-containing compound as well as preparation method and application thereof

-

Paragraph 0075; 0112; 0151; 0152, (2019/01/06)

The application provides a substituted p-chlorophenyl acetylpiperazine-containing compound as well as a preparation method and application of the substituted p-chlorophenyl acetylpiperazine-containingcompound. The compound has the structure shown in the formula (I), and has better Akt1 inhibitory activity or growth inhibitory activity to MCL cell lines.

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