107246-45-7

Upstream product

• 107246-17-3 α-Benzyl-N-(1,2:3,4-di-O-cyclohexyliden-6-desoxy-α-D-galactopyranos-6-yliden)valin-methylester 
• 107246-14-0 N-(1,2:3,4-Di-O-cyclohexyliden-6-desoxy-α-D-galactopyranos-6-yliden)valin-methylester 
• 4070-48-8 L-Valine methyl ester 

Relevant academic research and scientific papers

Asymmetric Synthesis of Methyl α-Alkyl-valinates, -leucinates, and -isoleucinates Using (Cyclohexylidene-protected) D-Galactodialdehyde as Chiral Auxiliary

The Schiff bases 2 from protected D-galactodialdehyde 1 and methyl valinate, -leucinate, and -isoleucinate were diastereoselectively alkylated via the lithium derivatives 3.The asymmetric induction of the alkylation step varied from 23 to >95percent.Upon hydrolysis the alkylation products 5-7 furnished the optically active α-alkylated methyl (S)-valinates 8, -leucinates 10, and -isoleucinates 11.