1072792-33-6

Basic information

• Product Name: (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester
• Synonyms: (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester
• CAS NO: 1072792-33-6
• Molecular Weight: 209.673
• Mol File: 1072792-33-6.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester(1072792-33-6)
• EPA Substance Registry System: (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester(1072792-33-6)

Safety Data

• Hazardous Substances Data: 1072792-33-6(Hazardous Substances Data)

Usage

General Description

(R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester is a chemical compound commonly used in the synthesis of pharmaceuticals and as a reagent in organic chemistry. It is a chiral compound with a tert-butyl ester group and a chloro-hydroxypropylcarbamic acid moiety. Due to its chiral nature, it can exhibit different biological activities and interactions, making it potentially useful in the development of new drugs. Its chemical structure and properties make it suitable for various applications in the pharmaceutical and chemical industries, making it a valuable and versatile compound for research and development purposes.

Upstream product

• 51594-55-9 (R)-(-)-epichlorohydrin 
• 4248-19-5 tert-butyl carbazate 
• 106-89-8 epichlorohydrin 

Downstream Products

• 149057-20-5 (R)-<<(tert-butoxycarbonyl)amino>methyl>oxirane 
• 1072792-43-8 (R)-5-aminomethyl-3-(3-fluoro-4-methyl-phenyl)-oxazolidin-2-one 

Relevant articles and documents

Asymmetric aminolytic kinetic resolution of racemic epoxides using recyclable chiral polymeric Co(III)-salen complexes: A protocol for total utilization of racemic epoxide in the synthesis of (R)-naftopidil and (S)-propranolol

Chiral polymeric Co(III) salen complexes with chiral ((R)/(S)-BINOL, diethyl tartrate) and achiral (piperazine and trigol) linkers with varying stereogenic centers were synthesized for the first time and used as catalysts for aminolytic kinetic resolution (AKR) of a variety of terminal epoxides and glycidyl ethers to get enantio-pure epoxides (ee, 99%) and N-protected β-amino alcohols (ee, 99%) with quantitative yield in 16 h at RT under optimized reaction conditions. This protocol was also used for the synthesis of two enantiomerically pure drug molecules (R)-Naftopidil (α1- blocker) and (S)-Propranolol (β-blocker) as a key step via AKR of single racemic naphthylglycidyl ether with Boc-protected isoproylamine with 100% epoxide utilization at 1 g level. The catalyst 1 was successfully recycled for a number of times.

OXAZOLIDINONE ANTIBIOTIC DERIVATIVES

The invention relates to antibacterial compounds of formula (I) wherein R1 is hydrogen, halogen, hydroxy, alkoxy or cyano; Y1 and Y2 each represent CH, one or two of U, V, W and X represent(s) N and the remaining each repr