149057-20-5

Basic information

• Product Name: Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI)
• Synonyms: Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI);(R)-N-Boc-2,3-epoxypropylamine;(R)-tert-Butyl (oxiran-2-ylMethyl)carbaMate;(R)-1-(t-Butoxycarbonyl)-2,3-oxiranylaMine
• CAS NO: 149057-20-5
• Molecular Formula: C₈H₁₅NO₃
• Molecular Weight: 173.2096
• Product Categories: N-BOC
• Mol File: 149057-20-5.mol
• Article Data: 26

Chemical Properties

• Melting Point: 76-77 °C
• Boiling Point: 262.908°C at 760 mmHg
• Flash Point: 112.803°C
• Appearance: /
• Density: 1.081g/cm³
• Vapor Pressure: 0.011mmHg at 25°C
• Refractive Index: 1.462
• PKA: 12.45±0.46(Predicted)
• CAS DataBase Reference: Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI)(149057-20-5)
• EPA Substance Registry System: Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI)(149057-20-5)

Safety Data

• Hazardous Substances Data: 149057-20-5(Hazardous Substances Data)

Usage

General Description

Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI) is a chemical compound with a complex name. It is a derivative of carbamic acid and is also known as t-butyl (2R)-hydroxymethylaziridine. Carbamic acid, [(2R)-oxiranylmethyl]-, 1,1-dimethylethyl ester (9CI) is a versatile building block in organic synthesis and is commonly used as a reagent in chemical reactions. It has a t-butyl ester group and an oxirane ring, making it useful in the formation of various organic compounds and pharmaceuticals. It is important for researchers and chemists in the development of new molecules and materials.

InChI:InChI=1/C8H15NO3/c1-8(2,3)12-7(10)9-4-6-5-11-6/h6H,4-5H2,1-3H3,(H,9,10)/t6-/m1/s1

Upstream product

• 24424-99-5 di-tert-butyl dicarbonate 
• 148982-76-7 tert-butyl N-(2-oxiranylmethyl)carbamate 
• 1072792-33-6 (R)-3-chloro-2-hydroxypropylcarbamic acid tert-butyl ester 
• 148983-23-7 (R)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane 
• 148983-24-8 (R)-1-<(tert-butoxycarbonyl)amino>-2-hydroxy-3-<<(4-methylphenyl)sulfonyl>oxy>propane 
• 34619-03-9 tert-butyldicarbonate 
• 570390-94-2 tert-butyl-3-chloro-2-hydroxypropylcarbamate 
• 137618-48-5 tert-butyl N-(2,3-dihydroxypropyl)carbamate 
• 78888-18-3 N-tert-butoxycarbonylprop-2-en-1-amine 

Downstream Products

• 148983-25-9 (S)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane 
• 148983-23-7 (R)-1-<(tert-butoxycarbonyl)amino>-2,3-dihydroxypropane 
• 161513-47-9 (S)-<<(tert-butoxycarbonyl)amino>methyl>oxirane 
• 313476-66-3 tert-butyl 3-(4-cyanophenoxy)-2-hydroxypropylcarbamate 
• 144912-84-5 (3-amino-2-hydroxypropyl)carbamic acid 1,1-dimethylethyl ester 
• 1283093-89-9 C₁₀₈H₁₆₄N₆O₂₇Si₅ 
• 162541-45-9 (RS)-2-<(tert-Butoxycarbonyl)amino>-1-benzylethanol 

Relevant articles and documents

Coupling of CO2and epoxides catalysed by novel: N-fused mesoionic carbene complexes of nickel(ii)

We report the syntheses of two rigid mesoionic carbene (MIC) ligands with a carbazole backbone via an intramolecular Finkelstein-cyclisation cascade and investigate their coordination behavior towards nickel(ii) acetate. Despite the nickel(ii) carbene complexes 4a,b showing only minor differences in their chemical composition, they display curious differences in their chemical properties, e.g. solubility. Furthermore, the potential of these novel MIC complexes in the coupling of carbon dioxide and epoxides as well as the differences in reactivity compared to classical NHC-derived complexes are evaluated.

TYK2 INHIBITORS AND USES THEREOF

The present invention provides compounds, compositions thereof, and methods of using the same for the inhibition of TYK2, and the treatment of TYK2-mediated disorders.

Novel synthesis of fluorochrome-coupled zoledronate with preserved functional activity on gamma/delta T cells and tumor cells

In addition to their effects on bone resorption, nitrogen-containing bisphosphonates (N-BP) selectively activate γδ T cells, an innate-like immune cell population with potent anti-tumor activity. N-BP stimulate γδ T cells through induction of intracellular accumulation of mevalonate pathway-derived pyrophosphates, which are strong and selective antigens for human γδ T cells. The most potent among several classes of N-BP is zoledronate (ZOL). To study the uptake of ZOL and its immunological consequences in the γδ T cell/tumor cell interplay, we have synthesized a novel fluorescently labeled ZOL derivative termed FluorZOL by covalently coupling ZOL to carboxyfluorescein succinidimyl ester. Here we describe in detail the synthesis of FluorZOL and we further show that FluorZOL is functionally fully active as revealed by the selective expansion of γδ T cells and the enhancement of tumor cell lysis by γδ T cells.