1072811-65-4Relevant academic research and scientific papers
Proline isosteres in a series of 2,4-disubstituted pyrrolo[1,2-f][1,2,4] triazine inhibitors of IGF-1R kinase and IR kinase
Sampognaro, Anthony J.,Wittman, Mark D.,Carboni, Joan M.,Chang, Chiehying,Greer, Ann F.,Hurlburt, Warren W.,Sack, John S.,Vyas, Dolatrai M.
experimental part, p. 5027 - 5030 (2010/10/20)
Pyrrolidine, pyrrolidinone, carbocyclic, and acyclic groups were used as isosteric proline replacements in a series of insulin-like growth factor I receptor kinase/insulin receptor kinase inhibitors. Examples that were similar in potency to proline-containing reference compounds were shown to project a key fluoropyridine amide into a common space, while less potent compounds were not able to do so for reasons of stereochemistry or structural rigidity.
PYRROLOTRIAZINE KINASE INHIBITORS
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, (2008/12/08)
The invention provides compounds of formula (I) and pharmaceutically acceptable salts thereof. The formula I compounds inhibit tyrosine kinase activity thereby making them useful as anti-cancer agents and for the treatment of Alzheimer's Disease.
