107288-79-9Relevant academic research and scientific papers
Synthesis of Quinazoline and Quinazolinone Derivatives via Ligand-Promoted Ruthenium-Catalyzed Dehydrogenative and Deaminative Coupling Reaction of 2-Aminophenyl Ketones and 2-Aminobenzamides with Amines
Kirinde Arachchige, Pandula T.,Yi, Chae S.
supporting information, (2019/05/08)
The in situ formed ruthenium catalytic system ([Ru]/L) was found to be highly selective for the dehydrogenative coupling reaction of 2-aminophenyl ketones with amines to form quinazoline products. The deaminative coupling reaction of 2-aminobenzamides with amines led to the efficient formation of quinazolinone products. The catalytic coupling method provides an efficient synthesis of quinazoline and quinazolinone derivatives without using any reactive reagents or forming any toxic byproducts.
STUDIES WITH REISSERT COMPOUNDS. PART 17. MONO-REISSERT COMPOUND FORMATION AT THE 1,2-POSITION OF THE QUINAZOLINE SYSTEM.
Uff, Barrie C.,Joshi, Bijaya L.,Popp, Frank D.
, p. 2295 - 2304 (2007/10/02)
4-Substituted quinazolines have been selectively converted into mono-Reissert compounds at the 1,2-position by use of acid chlorides and trimethylsilyl cyanide.Various reactions of the quinazoline Reissert compounds are reported.For example, conjugate base generation at the 2-position leads to a 1,2-rearrangement, whereas substitution occurs in the presence of an alkyl halide, providing, after hydrolysis, 2-alkyl-4-phenylquinazolines in good yield.Ring annellation by intramolecular alkylation is also reported.The quinazoline Reissert compound conjugate base reacts with aldehydes to give alcohol esters which can further be converted, via the alcohol and use of phosgene, to novel oxazoloquinazoline derivatives.
SYNTHESIS OF QUINAZOLINES
Bergman, Jan,Brynolf, Anna,Elman, Bjoern,Vuorinen, Eino
, p. 3697 - 3706 (2007/10/02)
Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy
