107288-99-3Relevant academic research and scientific papers
Ring forming reactions of imines of 2-aminobenzaldehyde and related compounds
Wiklund, Per,Bergman, Jan
, p. 367 - 372 (2003)
By addition of organometallic reagents to 2-aminobenzonitriles followed by quenching with suitable electrophiles (acyl halides, aldehydes and ketones), several types of 6-membered benzofused aromatic and non-aromatic nitrogen heterocycles could be obtained. Rearrangements leading to 1,2-dihydro-3H-1,4-benzodiazepin-3-ones and preparation of various quinazolines are described.
SYNTHESIS OF QUINAZOLINES
Bergman, Jan,Brynolf, Anna,Elman, Bjoern,Vuorinen, Eino
, p. 3697 - 3706 (2007/10/02)
Grignard reagents reacted with 2-aminobenzonitrile to give the intermediate (10), which readily could be cyclized to quinazolines by reaction with carbonyl compounds (e.g. acid chlorides, anhydrides, formates and oxalates).The intermediate (10) and aldehy
