1072895-84-1 Usage
Description
2,4-dichloro-7-Methoxy-6-Methylquinazoline is a quinazoline derivative with a molecular formula C10H8Cl2N2O. It is characterized by the presence of two chlorine atoms, a methoxy group, and a methyl group. This chemical compound is widely used in organic synthesis and medicinal chemistry research, and has demonstrated potential as an anti-cancer agent. Its unique structure and properties make it a valuable compound for the development of new pharmaceuticals and agrochemicals.
Uses
Used in Pharmaceutical Industry:
2,4-dichloro-7-Methoxy-6-Methylquinazoline is used as a key intermediate in the synthesis of various pharmaceuticals. Its unique structure allows for the development of new drugs with improved therapeutic properties.
Used in Agrochemical Industry:
2,4-dichloro-7-Methoxy-6-Methylquinazoline is used as a building block in the synthesis of agrochemicals, contributing to the development of new pesticides and herbicides with enhanced efficacy and selectivity.
Used in Anticancer Research:
2,4-dichloro-7-Methoxy-6-Methylquinazoline is used as a potential anti-cancer agent. Its structure and properties make it a promising candidate for the development of new cancer therapies, offering the potential to target specific cancer cells and inhibit their growth.
Used in Antifungal and Antibacterial Applications:
Due to its demonstrated antifungal and antibacterial activities, 2,4-dichloro-7-Methoxy-6-Methylquinazoline is used in the development of new antimicrobial agents. Its versatility makes it a valuable compound for addressing the growing concerns of antibiotic resistance and the need for new antifungal treatments.
Check Digit Verification of cas no
The CAS Registry Mumber 1072895-84-1 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,2,8,9 and 5 respectively; the second part has 2 digits, 8 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 1072895-84:
(9*1)+(8*0)+(7*7)+(6*2)+(5*8)+(4*9)+(3*5)+(2*8)+(1*4)=181
181 % 10 = 1
So 1072895-84-1 is a valid CAS Registry Number.
1072895-84-1Relevant articles and documents
Discovery of Potent and Selective Inhibitors for G9a-Like Protein (GLP) Lysine Methyltransferase
Xiong, Yan,Li, Fengling,Babault, Nicolas,Dong, Aiping,Zeng, Hong,Wu, Hong,Chen, Xin,Arrowsmith, Cheryl H.,Brown, Peter J.,Liu, Jing,Vedadi, Masoud,Jin, Jian
, p. 1876 - 1891 (2017/03/17)
G9a-like protein (GLP) and G9a are highly homologous protein lysine methyltransferases (PKMTs) sharing approximately 80% sequence identity in their catalytic domains. GLP and G9a form a heterodimer complex and catalyze mono- and dimethylation of histone H3 lysine 9 and nonhistone substrates. Although they are closely related, GLP and G9a possess distinct physiological and pathophysiological functions. Thus, GLP or G9a selective small-molecule inhibitors are useful tools to dissect their distinct biological functions. We previously reported potent and selective G9a/GLP dual inhibitors including UNC0638 and UNC0642. Here we report the discovery of potent and selective GLP inhibitors including 4 (MS0124) and 18 (MS012), which are >30-fold and 140-fold selective for GLP over G9a and other methyltransferases, respectively. The cocrystal structures of GLP and G9a in the complex with either 4 or 18 displayed virtually identical binding modes and interactions, highlighting the challenges in structure-based design of selective inhibitors for either enzyme.
