1072913-34-8Relevant academic research and scientific papers
Access to quinolines through gold-catalyzed intermolecular cycloaddition of 2-aminoaryl carbonyls and internal alkynes
Cai, Shuting,Zeng, Jing,Bai, Yaguang,Liu, Xue-Wei
experimental part, p. 801 - 807 (2012/02/16)
A facile and general method leading to polyfunctionalized quinolines was developed. In the presence of a highly efficient combination encompassing (PPh)3AuCl and AgOTf, the reactions between 2-aminocarbonyls and an array of internal alkynes pro
Cascade synthesis of 3-quinolinecarboxylic ester via benzylation/ propargylation-cyclization
Fan, Jinmin,Wan, Changfeng,Sun, Gaojun,Wang, Zhiyong
supporting information; experimental part, p. 8608 - 8611 (2009/04/04)
(Chemical Equation Presented) Reactions of 2-amino-aryl alcohols with β-ketoesters catalyzed by a catalytic amout of FeCl3 via tandem benzylation-cyclization produce the corresponding 3-quinolinecarboxylic esters in good to high yields. Extending this methodology to propargylation- cyclization, 2-nitrophenyl propargyl alcohols with β-ketoesters catalyzed by FeCl3 and SnCl2 also produce the 4-alkyne-3- quinolinecarboxylic esters. The mechanistic details of this benzylation/ propargylation and cyclization cascade process are also discussed.
