1073149-53-7Relevant academic research and scientific papers
Solution-phase synthesis of first-generation tetraester dendritic branches involving microwave and/or ultrasonic irradiation
Wiesbrock, Frank,Patteux, Claudine,Olszewski, Tomasz K.,Blanrue, Amelie,Heropoulos, Georgios A.,Steele, Barry R.,Micha-Screttas, Maria,Calogeropoulou, Theodora
experimental part, p. 4344 - 4349 (2009/04/11)
Trifunctionalized aromatic cores were selectively protected to obtain precursors for bidirectional dendritic unit growth through stepwise divergent syntheses. The synthesis of first-generation dendrimer building blocks was performed by nucleophilic substitution of bromomethyl-substituted aromatic cores with diethyl malonate anions in the presence of carbonate in halogen-free solvents. The screening of the reaction parameters revealed the optimum conditions for small- and larger-scale synthesis: these require microwave or ultrasonic irradiation to achieve yields around 70% in reaction times as short as 15 min. As a result of the heterogeneity of the reaction mixtures, efficient stirring was important to suppress by-product formation. Wiley-VCH Verlag GmbH & Co. KGaA, 2008.
