107356-01-4Relevant academic research and scientific papers
INHIBITING FATTY ACID SYNTHASE (FASN)
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Paragraph 0226, (2020/04/30)
The present disclosure is directed to inhibitors of FASN. The compounds can be useful in the treatment of disease or disorders associated with the inhibition of FASN. For instance, the disclosure is concerned with compounds and compositions for inhibition
Synthesis and Structure-Activity Studies of Some Disubstituted Phenylisoxazoles against Human Picornavirus
Diana, Guy D.,Cutcliffe, David,Oglesby, Richard C.,Otto, Michael J.,Mallamo, John P.,et al.
, p. 450 - 455 (2007/10/02)
A number 2,6-disubstituted analogues of disoxaril, a broad spectrum antipicornavirus agent, have been prepared and evaluated against several rhinovirus serotypes.A QSAR study revealed that the mean MIC () against five rhinovirus serotypes correlated well with log P.The 2,6-dichloro analogue, 15, was highly effective in vitro against rhinoviruses with an MIC80 of 0.3 μM, as well as against several enteroviruses, and was also effective in preventing paralysis in mice infected with coxsackievirus A-9.
