107366-71-2Relevant academic research and scientific papers
Design, synthesis, MTT assay, DNA interaction studies of platinum(II) complexes
Lunagariya, Miral V.,Thakor, Khyati P.,Waghela, Bhargav N.,Vaidya, Foram U.,Pathak, Chadramani,Patel, Mohan N.
, p. 14 - 31 (2018)
The square planar Pt(II) complexes of the type [Pt(Ln)(Cl2)] (where Ln?=?L1?3?=?thiophene-2-carboxamide derivatives and L4?6?=?thiophene-2-carbothioamide derivatives) have been synthesized and characterized by physicochemical and various spectroscopic studies. MIC method was employed to inference the antibacterial potency of complexes in reference to free ligands and metal salt. Characteristic binding constant (Kb) and binding mode of complexes with calf thymus DNA (CT-DNA) were determined using absorption titration (0.76–1.61?×?105?M?1), hydrodynamic chain length assay and fluorescence quenching analysis, deducing the partial intercalative mode of binding. Molecular docking calculation displayed free energy of binding in the range of –260.06 to –219.63 kJmol?1. The nuclease profile of complexes towards pUC19 DNA shows that the complexes cleave DNA more efficiently compared to their respective metal salt. Cytotoxicity profile of the complexes on the brine shrimp shows that all the complex exhibit noteworthy cytotoxic activity with LC50 values ranging from 7.87 to 15.94?μg/mL. The complexes have been evaluated for cell proliferation potential in human colon carcinoma cells (HCT 116) and IC50 value of complexes by MTT assay (IC50?=?125–1000?μg/mL).
Aminolysis of aryl dithio-2-thiophenates and dithio-2-furoates in acetonitrile
Oh, Hyuck Keun,Woo, So Young,Shin, Chul Ho,Lee, Ikchoon
, p. 849 - 857 (2007/10/03)
The aminolyses of the title substrates with anilines and benzylamines are investigated in acetonitrile. A clean second-order kinetics is obtained with a first-order rate law in the amine concentration, which is uncomplicated by the fast proton transfer st
A FRIEDEL-CRAFTS SYNTHESIS OF N-SUBSTITUTED THIOPHENECARBOTHIOAMIDES
Jagodzinski, Tadeusz,Jagodzinska, Elzbieta,Jablonski, Zygfryd
, p. 3683 - 3688 (2007/10/02)
The reaction of thiophene and 2,5-dimethylthiophene with isothiocyanates in the presence of aluminium chloride in nitromethane gave rise to the formation of the N-substituted carbothioamides of thiophene-2-carboxylic and 2,5-dimethyl-thiophene-3-carboxylic acid, respectively.Under similar conditions, 2-ethylthio-5-methylthiophene was attacked by the reagent at the carbon atom adjacent to the ethylthio group, whereas 2-phenyl-5-methylthiophene yielded a mixture of the 3- and 4-carbothioamides.
