107401-68-3Relevant academic research and scientific papers
One-pot sequential multicomponent route to 2,4-diaminothiazoles - A facile approach to bioactive agents for cancer therapeutics
Sreejalekshmi, Kumaran G.,Rajasekharan, Kallikat N.
, p. 3627 - 3629 (2012)
A facile one-pot sequential three-component route to 2,4-diaminothiazoles is reported. The new approach employs the mildest reaction conditions and commercially available reagents to generate diverse 2-alkyl/arylamino-4-amino-5- aroyl/heteroylthiazoles in short reaction times, good yield, and purity.
An efficient protocol for solid phase aminothiazole synthesis
Sreejalekshmi, Kumaran G.,Devi, Satyabhama K.C.,Rajasekharan, Kallikat N.
, p. 6179 - 6182 (2006)
An efficient synthesis of 2,4-diamino-5-ketothiazoles under solid phase conditions has been achieved by the reaction of polymer supported amidinothioureas with α-haloketones. This novel synthetic approach involving traceless cleavage from the support is s
DIAMINOTHIAZOLE COMPOUNDS, COMPOSITIONS AND METHODS OF USE
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Paragraph 00163; 00164; 00165; 00184, (2018/05/27)
The disclosure relates to diaminothiazole derivatives of formula (I) where the variables are as defined herein, pharmaceutical compositions containing such compounds, and methods for the use of such compounds and compositions for the treatment of hyperpro
2-Arylamino-4-amino-5-aroylthiazoles. "One-pot" synthesis and biological evaluation of a new class of inhibitors of tubulin polymerization
Romagnoli, Romeo,Baraldi, Pier Giovanni,Carrion, Maria Dora,Cruz-Lopez, Olga,Cara, Carlota Lopez,Basso, Giuseppe,Viola, Giampietro,Khedr, Mohammed,Balzarini, Jan,Mahboobi, Siavosh,Sellmer, Andreas,Brancale, Andrea,Hamel, Ernest
supporting information; experimental part, p. 5551 - 5555 (2010/02/28)
The essential role of microtubules in mitosis makes them a major target of compounds useful for cancer therapy. In our search for potent antitumor agents, a novel series of 2-anilino-4-amino-5-aroylthiazoles was synthesized and evaluated for antiprolifera
Studies on the Synthesis of 5-Acyl-2,4-diaminothiazoles from Amidinothioureas
Rajasekharan, K. N.,Nair, K. P.,Jenardanan, G. C.
, p. 353 - 355 (2007/10/02)
1-Alkyl or aryl-3-amidinothioureas with or without substituents on the amidino moiety react with α-haloketones to yield 5-acyl-2,4-diaminothiazoles.
