107446-43-5Relevant academic research and scientific papers
Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones
Shih, Hsiencheng,Deng, Lynn,Carrera, Carlos J.,Adachi, Souichi,Cottam, Howard B.,Carson, Dennis A.
, p. 487 - 490 (2007/10/03)
Novel substituted 6,7-dimethoxy-1-tetralones and 5,6-dimethoxy-1-indanones have been synthesized and evaluated for their cytotoxicity. Compounds with 3'-lipophilic, 3',5'-dilipophilic, or 3',5'-dilipophilic-4'-hydrophilic substituents on (E)-2-benzylidene moiety showed highly cytotoxic effects. The unique structure of 42 possibly matches the pharmacophore features for these cytotoxic compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.
