107446-44-6

Upstream product

• 120-14-9 3,4-dimethoxy-benzaldehyde 
• 13575-75-2 6,7-dimethoxy-1-oxo-1,2,3,4-tetrahydronaphthalene 

Downstream Products

• 112051-41-9 3-(2,3-Dimethoxy-phenyl)-7,8-dimethoxy-3,3a,4,5-tetrahydro-benzo[g]indole-2,2-dicarboxylic acid diethyl ester 
• 107446-48-0 (Dimethoxy-3',4')-benzyl-2 dimethoxy-6,7 tetralone 
• 107446-58-2 (Dimethoxy-3',4')-benzyl-3 dimethoxy-7,8 tetrahydro-2,3,4,5 1H benzazepine-2 one-1 
• 107446-55-9 (Dimethoxy-3',4')-benzyl-3 dimethoxy-7,8 tetrahydro-2,3,4,5 1H benzazepine-1 one-2 
• 107446-52-6 Oxime de la (dimethoxy-3',4')-benzyl-2 dimethoxy-6,7 tetralone 
• 107446-65-1 (Dimethoxy-3',4')-benzyl-3 dimethoxy-7,8 tetrahydro-2,3,4,5 1H benzazepine-2 

Relevant academic research and scientific papers

Rational design, synthesis and structure-activity relationships of antitumor (E)-2-benzylidene-1-tetralones and (E)-2-benzylidene-1-indanones

Novel substituted 6,7-dimethoxy-1-tetralones and 5,6-dimethoxy-1-indanones have been synthesized and evaluated for their cytotoxicity. Compounds with 3'-lipophilic, 3',5'-dilipophilic, or 3',5'-dilipophilic-4'-hydrophilic substituents on (E)-2-benzylidene moiety showed highly cytotoxic effects. The unique structure of 42 possibly matches the pharmacophore features for these cytotoxic compounds. (C) 2000 Elsevier Science Ltd. All rights reserved.

Indanone and tetralone compounds for inhibiting cell proliferation

A new family of indanone and tetralone tubulin-binding compounds (TBs) is disclosed. Unlike classical TBs, which inhibit mitosis among affected dividing cells, the TBs of the invention possess two unique properties: (1) they induce apoptosis among stationary phase (non-dividing) malignant cells, yet do not impair the viability of normal nonproliferating cells; and, (2) they affect cells which have acquired MDR more powerfully than they affect cells without MDR. Thus, the TBs of the invention provide means to target malignant cells for chemotherapy, even after previous therapies have failed, without affecting normal cells and tissues in the host.