1075-81-6Relevant academic research and scientific papers
Ruthenium-catalyzed asymmetric hydrogenation of 3-oxoglutaric acid derivatives: A study of unconventional solvent and substituent effects
Li, Wanfang,Tao, Xiaoming,Ma, Xin,Fan, Weizheng,Li, Xiaoming,Zhao, Mengmeng,Xie, Xiaomin,Zhang, Zhaoguo
supporting information, p. 16531 - 16539 (2013/02/22)
A series of 3-oxoglutaric acid derivatives have been hydrogenated in different solvents in the presence of [RuCl(benzene)(S)-SunPhos]Cl (SunPhos=(2,2,2′,2′-tetramethyl-[4,4′-bibenzo[d][1,3]dioxole] -5,5′-diyl)bis(diphenylphosphine)). Unlike simple β-keto acid derivatives, these advanced analogues can be readily hydrogenated in uncommon solvents such as THF, CH2Cl2, acetone, and dioxane with high enantioselectivities. Two possible catalytic cycles have been proposed to explain the different reactivities of these 1,3,5-tricarbonyl substrates in the tested solvents. The C-2 and C-4 substituents had notable but irregular influence on the reactivity and enantioselectivity of the reactions. More pronounced solvent effects were observed: the ee values increased from around 20 % in EtOH or THF to 90 % in acetone. Inversion of the product configuration was observed when the solvent was changed from EtOH to THF or acetone, and a mixed solvent system can lead to better enantioselectivity than a single solvent. Pronounced solvent effects: 3-Oxoglutaric acid derivatives have been hydrogenated in various solvents with high enantioselectivities (see scheme). Inversions of the product configuration were observed when the solvent was changed. Mixed solvent systems can give better enantioselectivities than a single solvent.
FUSED HETEROCYCLIC COMPOUND
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Page/Page column 185, (2008/06/13)
The present invention provides a glucokinase activator containing a compound represented by the formula (I): wherein each symbol is as defined in the specification, or a salt thereof or a prodrug thereof. According to the present invention, a glucokinase activator useful as a pharmaceutical agent such as agent for the prophylaxis or treatment of diabetes, obesity and the like, and the like can be provided.
Structure-Activity Relationship Studies of Illudins: Analogues Possessing a Spiro-cyclobutane Ring
McMorris, Trevor C.,Cong, Qiang,Kelner, Michael J.
, p. 9648 - 9653 (2007/10/03)
Bicyclic and tricyclic analogues of anticancer sesquiterpene illudin S have been synthesized. These contain a spiro-cyclobutane instead of spiro-cyclopropane structure. The cytotoxicity of the former is less than that of the corresponding cyclopropane-containing compounds.
Use of malonic acid derivative compounds for retarding plant growth
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, (2008/06/13)
This invention relates to a method for retarding plant growth by applying to the plant an effective amount of a malonic acid derivative compound. This invention also relates to novel malonic acid derivative compounds and processes for the preparation thereof.
Synergistic plant growth regulator compositions
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, (2008/06/13)
This invention relates to synergistic plant growth regulator compositions containing (1) an ethylene response or ethylene-type response inducing agent and (11) a malonic acid derivative compound. This invention also relates to the use of said compositions
A NOVEL RING EXPANSION OF 1-CARBOETHOXY-1,1-TRIMETHYLENE-3-DIAZO-2-PROPANONE
Miller, R. D.,Theis, W.
, p. 2447 - 2450 (2007/10/02)
The title compound undergoes an unusual thermal cyclobutyl to cyclopentyl rearrangement initiated by the intramolecular reaction of ketene moiety produced in situ with the pendant functionality.
