1075-98-5

Basic information

• Product Name: 1,1-Cyclobutanediacetic acid
• Synonyms: 1,1-Cyclobutanediacetic acid;2,2'-(Cyclobutane-1,1-diyl)diacetic acid;cyclobutane-1,1-diacetic acid;(1-carboxymethylcyclobutyl)acetic acid
• CAS NO: 1075-98-5
• Molecular Formula: C₈H₁₂O₄
• Molecular Weight: 172.17848
• Mol File: 1075-98-5.mol
• Article Data: 3

Chemical Properties

• Melting Point: 140 °C
• Boiling Point: 388.4±15.0 °C(Predicted)
• Appearance: /
• Density: 1.286±0.06 g/cm3(Predicted)
• Storage Temp.: 2-8°C
• PKA: 4.42±0.10(Predicted)
• CAS DataBase Reference: 1,1-Cyclobutanediacetic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-Cyclobutanediacetic acid(1075-98-5)
• EPA Substance Registry System: 1,1-Cyclobutanediacetic acid(1075-98-5)

Safety Data

• Hazardous Substances Data: 1075-98-5(Hazardous Substances Data)

Usage

General Description

1,1-Cyclobutanediacetic acid is a chemical compound with the molecular formula C6H8O4. It is an organic compound that consists of a cyclobutane ring with two carboxylic acid functional groups attached. 1,1-Cyclobutanediacetic acid is used as a building block in the synthesis of other complex organic molecules and is also used in pharmaceutical research. It has potential applications in the development of new drugs and chemical processes. Additionally, 1,1-Cyclobutanediacetic acid is known for its ability to chelate metal ions, making it useful in the field of coordination chemistry. Overall, this compound has various industrial and scientific applications due to its unique structure and properties.

Upstream product

• 1073-90-1 2,2'-(cyclobutane-1,1-diyl)diacetonitrile 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 151-50-8 potassium cyanide 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 65478-57-1 1,1-bis-(iodomethyl)-cyclobutane 
• 22308-09-4 [1-(p-tolylsulfonyloxymethyl)cyclobutyl]methyl-4-methylbenzenesulfonate 
• 4415-73-0 [1-(hydroxymethyl)cyclobutyl]methanol 

Downstream Products

• 31058-02-3 spiro[3.5]nonan-7-one 

Relevant articles and documents

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as 1 using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-methyl compound. It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.

MACROCYCLIC COMPOUNDS FOR MODULATING IL-17

The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions