1075-98-5

Usage

Uses

Used in Pharmaceutical Research:
1,1-Cyclobutanediacetic acid is used as a building block for the synthesis of complex organic molecules, facilitating the development of new drugs and chemical processes. Its unique structure allows for the creation of novel compounds with potential therapeutic applications.
Used in Coordination Chemistry:
1,1-Cyclobutanediacetic acid is used as a chelating agent for metal ions, which is crucial in the field of coordination chemistry. This property enables the compound to form stable complexes with various metal ions, contributing to the advancement of chemical research and applications in different industries.
Used in Industrial Applications:
Due to its unique structure and properties, 1,1-Cyclobutanediacetic acid finds use in various industrial applications, where its ability to form stable complexes and participate in the synthesis of complex organic molecules is highly valued.

Upstream product

• 1073-90-1 2,2'-(cyclobutane-1,1-diyl)diacetonitrile 
• 3779-29-1 diethyl cyclobutane-1,1-dicarboxylate 
• 151-50-8 potassium cyanide 
• 4415-73-0 [1-(hydroxymethyl)cyclobutyl]methanol 
• 22308-09-4 [1-(p-tolylsulfonyloxymethyl)cyclobutyl]methyl-4-methylbenzenesulfonate 
• 5445-51-2 cyclobutane-1,1'-dicarboxylic acid 
• 65478-57-1 1,1-bis-(iodomethyl)-cyclobutane 

Downstream Products

• 31058-02-3 spiro[3.5]nonan-7-one 

Relevant academic research and scientific papers

Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists

5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as 1 using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-methyl compound. It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.

AMINOPYRAZOLONE DERIVATIVE

The present invention is intended to provide a compound or a pharmacologically acceptable salt thereof which has an excellent inhibitory action on the ATPase activity of a TIP48/TIP49 complex and as such, is useful for the treatment of tumors. [Solution] The present invention provides a compound having a structure represented by the general formula (I) or a pharmacologically acceptable salt thereof, and a pharmaceutical composition comprising the compound. In the formula, R1, R2, R3, R4, R5, R6, R7, and W are as defined in the present specification.

MACROCYCLIC COMPOUNDS FOR MODULATING IL-17

The invention relates generally to macrocyclic compounds of formula I and their therapeutic use. More particularly, the invention relates to macrocyclic compounds that modulate the activity of IL-17 and/or are useful in the treatment of medical conditions