65478-57-1 Usage
Uses
1. Used in Organic Synthesis:
1,1-Bis(iodoMethyl)cyclobutane is used as a key reactant for the synthesis of new oxaspiran systems. Its iodoMethyl groups facilitate the formation of new carbon-carbon bonds, which are crucial in constructing the desired oxaspiran ring structures. These systems are important in the development of novel pharmaceuticals, agrochemicals, and other specialty chemicals.
2. Used in Pharmaceutical Industry:
In the pharmaceutical industry, 1,1-Bis(iodoMethyl)cyclobutane is used as a building block for the development of new drugs. Its unique structure allows for the creation of diverse molecular frameworks that can be tailored to target specific biological receptors or enzymes, potentially leading to the discovery of new therapeutic agents.
3. Used in Material Science:
1,1-Bis(iodoMethyl)cyclobutane can also be utilized in the field of material science, particularly in the synthesis of novel polymers and other advanced materials. Its reactive iodoMethyl groups can be employed to create new polymer architectures with unique properties, such as enhanced mechanical strength, thermal stability, or chemical resistance.
4. Used in Chemical Research:
In academic and industrial research settings, 1,1-Bis(iodoMethyl)cyclobutane serves as a valuable tool for exploring new reaction pathways and understanding the fundamental principles of organic chemistry. Its unique reactivity can provide insights into the mechanisms of various chemical transformations, contributing to the advancement of chemical knowledge and the development of new synthetic strategies.
Check Digit Verification of cas no
The CAS Registry Mumber 65478-57-1 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 6,5,4,7 and 8 respectively; the second part has 2 digits, 5 and 7 respectively.
Calculate Digit Verification of CAS Registry Number 65478-57:
(7*6)+(6*5)+(5*4)+(4*7)+(3*8)+(2*5)+(1*7)=161
161 % 10 = 1
So 65478-57-1 is a valid CAS Registry Number.
65478-57-1Relevant academic research and scientific papers
Structure-activity relationship study of β-oxidation resistant indole-based 5-oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) receptor antagonists
Ye, Qiuji,Chourey, Shishir,Wang, Rui,Chintam, Nagendra Reddy,Gravel, Sylvie,Powell, William S.,Rokach, Joshua
, p. 4770 - 4776 (2017/09/27)
5-Oxo-6,8,11,14-eicosatetraenoic acid (5-oxo-ETE) is formed from 5S-hydroxy-6,8,11,14-eicosatetraenoic acid (5-HETE) by the 5-lipoxygenase (5-LO) pathway under conditions associated with oxidative stress. 5-Oxo-ETE is an important pro-inflammatory mediator, which stimulates the migration of eosinophils via a selective G-protein coupled receptor, known as the OXE receptor (OXE-R). Previously, we designed and synthesized structural mimics of 5-oxo-ETE such as 1 using an indole scaffold. In the present work, we added various substituents at C-3 of this moiety to block potential β-oxidation of the 5-oxo-valerate side chain, and investigated the structure-activity relationships of the resulting novel β-oxidation-resistant antagonists. Cyclopropyl and cyclobutyl substituents were well tolerated in this position, but were less potent as the highly active 3S-methyl compound. It seems likely that 3-alkyl substituents can affect the conformation of the 5-oxovalerate side chain containing the critical keto and carboxyl groups, thereby affecting interaction with the OXE-receptor.
