107536-85-6Relevant academic research and scientific papers
Enantio- and Diastereodivergent Sequential Catalysis Featuring Two Transition-Metal-Catalyzed Asymmetric Reactions
Abel-Snape, Xavier,Lautens, Mark,Masson-Makdissi, Jeanne,Prieto, Liher
supporting information, p. 16932 - 16936 (2021/07/02)
This study demonstrates the feasibility and inherent benefits of combining two distinct asymmetric transition-metal-catalyzed reactions in one pot. The reported transformation features a Pd-catalyzed asymmetric allylic alkylation and a Rh-catalyzed enantioselective 1,4-conjugate addition, effectively converting simple allyl enol carbonate precursors into enantioenriched cyclic ketones with two remote stereocenters. Despite the anticipated challenges associated with controlling stereoselectivity in such a complex system, the products are obtained in enantiomeric excesses ranging up to >99 % ee, exceeding those obtained from either of the individual asymmetric reactions. In addition, since the stereoselectivity of both steps is under catalyst control, this one-pot reaction is enantio- and diastereodivergent, enabling facile access to all stereoisomers from the same set of starting materials.
Regioselective silver-mediated Kondakov-Darzens olefin acylation
Barczak, Nicholas T.,Jarvo, Elizabeth R.
, p. 12912 - 12916 (2011/12/04)
Enone construction: A silver-mediated olefin acylation reaction is described, in which five-, six-, and -seven-membered rings, tetrasubstituted olefins, bridged bicycles, spirocycles, and benzoxepinones are prepared. Highly selective intermolecular reactions are coupled to a Nazarov cyclization for the effective preparation of cyclopentenones, including the core of modhephene (see scheme). Copyright
THE PALLADIUM (II) ACETATE PROMOTED 6-ENDO-TRIG CYCLIZATION OF 1,1-DIALKYL-2-SILYLOXY-1,5-DIENES.
Torres, Luz E.,Larson, Gerald L.
, p. 2223 - 2226 (2007/10/02)
A route to cyclohexenones via the treatment of selected γ,δ-unsaturated enol silyl ethers with palladium (II) acetate is presented.
