107550-89-0

Upstream product

• 35246-64-1 (6R,7R)-benzhydryl 3-(hydroxymethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 603-35-0 triphenylphosphine 
• 64308-63-0 (6R,7R)-benzhydryl 3-(chloromethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 
• 51761-83-2 (6R,7R)-benzhydryl 3-(iodomethyl)-8-oxo-7-(2-phenylacetamido)-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylate 

Downstream Products

• 91439-21-3 cephalosporin 3'-triphenylphosphonium ylide 
• 609812-77-3 (6R,7R)-8-Oxo-3-[(Z)-3-(2-oxo-2H-chromen-7-yloxy)-propenyl]-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 135299-73-9 Diphenylmethyl (6R,7R)-3-<(E)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 112953-21-6 Diphenylmethyl (6R,7R)-3-<(Z)-2-(4-Methyl-1,3-thiazol-5-yl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-72-8 3-styryl-Δ³-cephem 
• 135299-72-8 Diphenylmethyl (6R,7R)-7-phenylacetamido-3-<(Z)-2-phenylvinyl>ceph-3-em-4-carboxylate 
• 135299-76-2 Diphenylmethyl (6R,7R)-3-<4(RS)-3,3-Bis(ethoxycarbonyl)-1-pyrazolin-4-yl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-78-4 Diphenylmethyl (6R,7R)-3-<(1RS)-2,2-Bis(ethoxycarbonyl)cyclopropyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 135299-75-1 Diphenylmethyl (6R,7R)-3-<2,2-Bis(ethoxycarbonyl)vinyl>-7-phenylacetamidoceph-3-em-4-carboxylate 
• 852671-30-8 (5S,6R,7R)-5,8-Dioxo-3-[(Z)-3-(2-oxo-2H-chromen-7-yloxy)-propenyl]-7-phenylacetylamino-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid benzhydryl ester 
• 852671-27-3 (5S,6R,7R)-5,8-Dioxo-3-[(Z)-3-(2-oxo-2H-chromen-7-yloxy)-propenyl]-7-phenylacetylamino-5λ⁴-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 
• 609812-88-6 (6R,7R)-8-Oxo-3-[(Z)-3-(2-oxo-2H-chromen-7-yloxy)-propenyl]-7-phenylacetylamino-5-thia-1-aza-bicyclo[4.2.0]oct-2-ene-2-carboxylic acid 

Relevant academic research and scientific papers

Novel fluorogenic substrates for imaging β-lactamase gene expression

A new class of small nonfluorescent fluorogenic substrates becomes brightly fluorescent after β-lactamase hydrolysis with up to 153-fold enhancement in the fluorescence intensity. Less than 500 fM of β-lactamase in cell lysates can be readily detected, and β-lactamase expression in living cells can be imaged with a red fluorescence derivative. These new fluorogenic substrates should find uses in clinical diagnostics and facilitate the applications of β-lactamase as a biosensor. Copyright

An improved procedure for the preparation of a 3-(alkenyl) cephem derivative

A new, improved procedure for the preparation of phosphonium halide on route to 3-(alkenyl)cephem derivatives is described.The approach involves the one-pot reaction of the 3-hydroxymethyl cephem derivative 7 with methyltriphenoxyphosphonium iodide in dic