1075706-10-3Relevant academic research and scientific papers
Catalytic asymmetric syntheses of tyrosine surrogates
Han, Xiaojun,Civiello, Rita L.,Fang, Haiquang,Wu, Dedong,Gao, Qi,Chaturvedula, Prasad V.,Macor, John E.,Dubowchik, Gene M.
experimental part, p. 8502 - 8510 (2009/04/04)
(Chemical Equation Presented) Amino acid esters 5-11 as tyrosine mimics have been synthesized in excellent enantioselectivity (up to 99.6% ee) and in good overall chemical yields. The key step in the sequence was the Burk's [Rh(COD)(2R,5R)-Et-DuPhos]BF4-catalyzed asymmetric hydrogenation of enamides with a variety of reactive functional groups.
