1075726-88-3 Usage
Description
(1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-methoxycarbonylethyl-isoquinolinium besylate is a complex organic compound with a unique chemical structure. It is characterized by its isoquinolinium core, which is substituted with various functional groups, including methoxy, dimethoxy, and methoxycarbonylethyl moieties. (1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-methoxycarbonylethyl-isoquinolinium besylate is synthesized through a series of chemical reactions and is known for its potential applications in the pharmaceutical industry.
Uses
Used in Pharmaceutical Industry:
(1R-cis)-1-[(3,4-dimethoxyphenyl)methyl]-1,2,3,4-tetrahydro-6,7-dimethoxy-2-methyl-2-methoxycarbonylethyl-isoquinolinium besylate is used as a reactant in the preparation of cisatracurium compounds. These compounds are therapeutically useful as nondepolarizing neuromuscular blocking agents, which are essential in medical procedures that require muscle relaxation, such as surgeries and mechanical ventilation.
Application Reason:
The compound's unique structure and functional groups contribute to its reactivity and compatibility with other molecules in the synthesis process. Its use in the preparation of cisatracurium compounds highlights its potential as a valuable intermediate in the development of new pharmaceuticals with improved efficacy and safety profiles.
Check Digit Verification of cas no
The CAS Registry Mumber 1075726-88-3 includes 10 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 7 digits, 1,0,7,5,7,2 and 6 respectively; the second part has 2 digits, 8 and 8 respectively.
Calculate Digit Verification of CAS Registry Number 1075726-88:
(9*1)+(8*0)+(7*7)+(6*5)+(5*7)+(4*2)+(3*6)+(2*8)+(1*8)=173
173 % 10 = 3
So 1075726-88-3 is a valid CAS Registry Number.
1075726-88-3Relevant articles and documents
Preparation method and application of cisatracurium besilate
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, (2021/05/12)
The invention provides a preparation method and application of cisatracurium besylate, and the preparation method comprises the following steps: (1) dissolving R-tetrahydropapaverine-N-acetyl-L-leucine salt, adjusting the pH value with an alkaline solution, and then mixing with methyl 3-bromopropionate and alkali for reaction to obtain an intermediate A; (2) mixing and reacting the intermediate A obtained in the step (1) with alkali to obtain an intermediate B; (3) mixing and reacting the intermediate B obtained in the step (2) with a methylation reagent to obtain an intermediate C; and (4) mixing and reacting the intermediate C obtained in the step (3), a catalyst and a dehydrating agent to obtain cisatracurium besylate. The preparation method provided by the invention is safe in production process, high in yield, few in isomer and low in maximum single impurity.
PROCESS FOR PRODUCING CISATRACURIUM COMPOUNDS AND ASSOCIATED INTERMEDIATES
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Page/Page column 27-28, (2008/12/08)
The present invention provides processes for producing isoquinolinium compounds, and for converting them into cisatracurium salts, e.g., cisatracurium besylate
