1075754-40-3

Upstream product

• 1075754-38-9 4-oxo-2-phenyl-4H-chromen-7-yl pivalate 
• 7294-51-1 2,4,6-tris(4-methoxyphenyl)boroxine 
• 5720-07-0 4-methoxyphenylboronic acid 
• 137527-18-5 4-oxo-2-phenyl-4H-chromen-6-yl 4-methylbenzenesulfonate 

Relevant academic research and scientific papers

Synthesis of Flavone Derivatives through Versatile Palladium-Catalyzed Cross-Coupling Reactions of Tosyloxy- and Mesyloxyflavones

Tosyloxy- and mesyloxyflavones derived from abundant and biologically important hydroxyflavones were used to synthesize a series of functionalized flavones through versatile palladium-catalyzed cross-coupling reactions. A Pd(OAc) 2 /2-[2-(dicyclohexylphosphino)phenyl]-1-methyl-1 H -indole system effectively catalyzed the reactions of a broad range of tosyloxy- and mesyloxyflavones as electrophilic coupling partners with various nucleophiles to give the corresponding products in good to excellent yields. Catalyst loadings of as little as 0.1 mol% Pd were successfully used. Importantly, we demonstrated that this protocol provided a significantly improved efficiency in the synthesis of a potential chromen-4-one-based analogue of a potent inhibitor of DNA-dependent protein kinase.

Biaryl construction via Ni-catalyzed C-O activation of phenolic carboxylates

Biaryl scaffolds were constructed via Ni-catalyzed aryl C-O activation by avoiding cleavage of the more reactive acyl C-O bond of aryl carboxylates. Now aryl esters, in general, can be successfully employed in cross-coupling reactions for the first time.