107597-91-1Relevant academic research and scientific papers
Synthesis of (-)-Fortamine and (+)-2-Deoxyfortamine From Resolved 3S,4S-Carbomethoxy-3-aminocyclohexen-4-ol
Knapp, Spencer,Sebastian, Mark J.,Ramanathan, Halasya,Bharadwaj, Parimal,Potenza, Joseph A.
, p. 3405 - 3410 (2007/10/02)
A three step sequence (Scheme I) starting with racemic 3,4-epoxycyclohexene (5) and (S)-α-methylbenzylamine gave 3S,4S-N-carbomethoxy-3-aminocyclohexen-4-ol (10) with chromatographic removal of the undesired 3R,4R byproduct.The absolute configuration of 1
Total Synthesis of (+/-)-Fortamine and (+/-)-2-Deoxyfortamine
Knapp, Spencer,Sebastian, Mark J.,Ramanathan, Halasya
, p. 4786 - 4788 (2007/10/02)
The efficient conversion of 1,3-cyclohexadiene (7) to the aminocyclitols (+/-)-fortamine (4, 13 steps, 30percent overall yield) and (+/-)-2-deoxyfortamine (5, 10 steps, 54percent overall yield) features four regiospecific epoxide-opening reactions.
