1076-51-3

Basic information

• Product Name: (S)-3-aMino-2-phenylpropanoic acid
• Synonyms: (S)-3-aMino-2-phenylpropanoic acid;(S)-3-Amino-2-phenyl-propionic acid
• CAS NO: 1076-51-3
• Molecular Formula: C₉H₁₁NO₂
• Molecular Weight: 165.18914
• Mol File: 1076-51-3.mol
• Article Data: 7

Chemical Properties

• Melting Point: 223-226 °C
• Boiling Point: 306.2±30.0 °C(Predicted)
• Appearance: /
• Density: 1.198±0.06 g/cm3(Predicted)
• Storage Temp.: Keep in dark place,Sealed in dry,Store in freezer, under -20°C
• PKA: 3.18±0.16(Predicted)
• CAS DataBase Reference: (S)-3-aMino-2-phenylpropanoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: (S)-3-aMino-2-phenylpropanoic acid(1076-51-3)
• EPA Substance Registry System: (S)-3-aMino-2-phenylpropanoic acid(1076-51-3)

Safety Data

• Hazardous Substances Data: 1076-51-3(Hazardous Substances Data)

Usage

General Description

(S)-3-amino-2-phenylpropanoic acid, also known as L-phenylalanine, is an essential amino acid that plays a crucial role in the synthesis of proteins and neurotransmitters in the body. It is a nonpolar, aromatic amino acid with a benzyl side chain, and it is found in many protein-rich foods such as meat, fish, eggs, and dairy products. In addition to its role in protein synthesis, L-phenylalanine is a precursor for the production of important neurotransmitters such as dopamine, norepinephrine, and epinephrine, which are crucial for mood regulation and stress response. It is also used in the production of food additives and pharmaceuticals. L-phenylalanine supplementation has been studied for its potential benefits in improving mood and mental alertness, but it should be used with caution in individuals with certain medical conditions such as phenylketonuria, as it can be harmful in high doses.

Upstream product

• 1070237-98-7 (S)-benzyl 3-nitro-2-phenylpropanoate 
• 1070685-01-6 ethyl 3-amino-2-phenylpropanoate 
• 129906-42-9 N-(3-phenyl-2-propenyl)benzamide 
• 1260684-66-9 (2S,5S)-1-benzoyl-2-isopropyl-5-phenylperhydropyrimidin-4-one 
• 215608-92-7 benzyl 3-(1,3-dioxoisoindolin-2-yl)-2-phenylpropanoate 
• 102-16-9 benzyl 2-phenylacetate 
• 54373-74-9 (RS)-3-phthalimido-2-phenylpropanoic acid chloride 
• 54373-73-8 3-(1,3-dioxoisoindolin-2-yl)-2-phenylpropanoic acid 
• 462655-04-5 (S)-3-(Benzyl-benzyloxycarbonyl-amino)-2-phenyl-propionic acid methyl ester 
• 22979-35-7 Methyl phenyldiazoacetate 
• 462655-05-6 (S)-3-(Benzyl-benzyloxycarbonyl-amino)-2-phenyl-propionic acid 
• 215608-93-8 (S)-3-(1,3-Dioxo-1,3-dihydro-isoindol-2-yl)-2-phenyl-propionic acid (R)-4,4-dimethyl-2-oxo-tetrahydro-furan-3-yl ester 
• 492-38-6 2-phenylacrylic acid 

Downstream Products

• 181140-88-5 N-Boc-phenylpropanoic acid 
• 77738-67-1 (+)-3,3-ethylenedithio-2-phenyl-1-phthalimidobutane 
• 77790-50-2 (+)-1-diazo-3-phenyl-4-phthalimidobutan-2-one 
• 77790-49-9 (+)-2-phenyl-3-phthalimidopropionyl chloride 
• 77738-66-0 (+)-2-phenyl-1-phthalimidobutan-3-one 
• 77738-68-2 (+)-2-phenyl-1-phthalimidobutane 
• 33603-06-4 (+)-1-amino-2-phenylbutane 
• 77790-48-8 (+)-2-phenyl-3-phthalimidopropionic acid 

Relevant articles and documents

Novel asymmetric catalytic nucleophilic fluorine heterocyclization reaction system and application thereof in chiral non-natural amino acid module synthesis

The invention discloses a novel asymmetric catalytic fluorine heterocyclization reaction system and application thereof. The novel asymmetric catalytic fluorine heterocyclization reaction system provided by the invention comprises a chiral iodine catalyst and etherified boron trifluoride, and is applied to a catalytic asymmetric nucleophilic fluorine heterocyclization reaction of unsaturated amide; a fluoro oxazine derivative is obtained through treatment after the reaction; and the obtained fluoro oxazine derivative is subjected to hydrolysis and oxidation reaction to obtain the chiral non-natural amino acid. The reaction system provided by the invention has the following advantages: etherified boron trifluoride is used as a fluorine reagent, is cheap and easy to obtain, and has good stability and low toxicity; the reaction conditions are mild; the chiral iodine catalyst is simple to prepare and does not need a complex ligand; the system is environment-friendly and free of heavy metal pollution and precious metal waste; the obtained product is a fluoro oxazine derivative active molecular structure unit with two chiral centers; chiral non-natural amino acid can be obtained through conversion reaction of the product; and the chemical selectivity and stereoselectivity of the reaction are good, and the yield and optical purity are high.

Organocatalytic asymmetric transferhydrogenation of β-nitroacrylates: Accessing β2-amino acids

We describe a highly efficient and enantioselective Hantzsch ester mediated conjugate reduction of β-nitroacrylates that is catalyzed by a Jacobsen thiourea catalyst as a key step in a new route to optically active β2-amino acids. Copyright

Catalytic enantioselective synthesis of β2-amino acids

A very direct approach for the synthesis of β-amino esters is provided by catalytic asymmetric C-H activation by means of carbenoid-induced C-H insertion (see scheme; Boc = butyloxycarbonyl; TFA = trifluoroacetic acid). The reactions described herein represent the first regioselective intermolecular C-H insertions occurring at a methyl site.