33603-06-4

Basic information

• Product Name: (+)-1-amino-2-phenylbutane
• Synonyms: (+)-1-amino-2-phenylbutane
• CAS NO: 33603-06-4
• Molecular Weight: 149.236
• Mol File: 33603-06-4.mol
• Article Data: 8

Chemical Properties

• CAS DataBase Reference: (+)-1-amino-2-phenylbutane(CAS DataBase Reference)
• NIST Chemistry Reference: (+)-1-amino-2-phenylbutane(33603-06-4)
• EPA Substance Registry System: (+)-1-amino-2-phenylbutane(33603-06-4)

Safety Data

• Hazardous Substances Data: 33603-06-4(Hazardous Substances Data)

Usage

General Description

(+)-1-amino-2-phenylbutane is a chemical compound with the molecular formula C10H15N. It is a chiral amine with a single chiral center and exists as two enantiomers, one of which has been identified as a naturally occurring alkaloid found in the leaves and stems of the plant Ilex guayusa. (+)-1-amino-2-phenylbutane has also been studied for its potential as a selective norepinephrine reuptake inhibitor, making it of interest in the development of novel pharmaceuticals for the treatment of conditions such as depression and anxiety. Additionally, (+)-1-amino-2-phenylbutane is used as a chiral building block in organic synthesis and has been the subject of research in the development of new synthetic methodologies.

Upstream product

• 13490-76-1 (S)-2-phenylbutyramide 
• 33442-47-6 (S)-2-phenylbutan-1-ol 
• 492-38-6 2-phenylacrylic acid 
• 4286-15-1 (S)-2-phenylbutyric acid 
• 1185653-84-2 (S)-1-azido-2-phenylbutane 
• 77738-67-1 (+)-3,3-ethylenedithio-2-phenyl-1-phthalimidobutane 
• 77790-50-2 (+)-1-diazo-3-phenyl-4-phthalimidobutan-2-one 
• 77790-49-9 (+)-2-phenyl-3-phthalimidopropionyl chloride 
• 77790-48-8 (+)-2-phenyl-3-phthalimidopropionic acid 
• 77738-66-0 (+)-2-phenyl-1-phthalimidobutan-3-one 
• 1076-51-3 (S)-3-amino-2-phenylpropanoic acid 
• 473996-37-1 (S)-N-Boc-N-(2-phenylbutyl)-isobutyramide 
• 473996-33-7 (S)-N-(2-phenylbutyl)isobutyramide 
• 64-04-0 phenethylamine 

Downstream Products

• 1565-75-9 2-phenyl-2-butanol 
• 614-14-2 1-Phenyl-1-butanol 
• 33442-47-6 (S)-2-phenylbutan-1-ol 
• 701-70-2 (S)-1-phenylbutan-2-ol 

Relevant articles and documents

METHODS OF MODULATING THE ACTIVITY OF THE MC1 RECEPTOR AND TREATMENT OF CONDITIONS RELATED TO THIS RECEPTOR

The present invention provides compounds of Formula (I) that are useful for binding and/or modulating the biological activity of the melanocortin-1 receptor (MC1R). Compounds of this invention can be used to treat diseases and/or conditions in which modulation of MC1R is beneficial. Such diseases and/or conditions include, but are not limited to, hyperpigmentation (including melasma), hypopigmentation (including vitiligo), melanoma, basal cell carcinoma, squamous cell carcinoma, erythropoietic protoporphyria, polymorphous light eruption, solar urticaria, photosensitivity, sunburn, inflammatory diseases, aberrant fibroblast activity and pain.

METHODS OF MODULATING THE ACTIVITY OF THE MC3 AND/OR MC4 RECEPTORS AND TREATMENT OF CONDITIONS RELATED TO THESE RECEPTORS

The present invention provides compounds of Formula (I) that are useful for modulating the biological activity of the melanocortin-3 receptor (MC3R) and / or the melanocortin-4 receptor (MC4R). Compounds of this invention can be used to treat diseases and/or conditions in which modulation of MC3R and / or MC4R is beneficial. Such diseases and/or conditions include, but are not limited to, obesity, eating disorders (such as cachexia, anorexia, weight gain, weight loss), metabolic syndrome, diabetes, sexual dysfunction (such as erectile dysfunction and female sexual dysfunction), anxiety, depression, inflammation, addiction and alcohol intake.

BICYCLIC LACTAM FACTOR VIIA INHIBITORS USEFUL AS ANTICOAGULANTS

The present invention provides novel bicyclic lactams derivatives, and analogues thereof, of Formula (I): or a stereoisomer, tautomer, pharmaceutically acceptable salt, solvate, or prodrug thereof, wherein the variables A, B, C, W, Y, Z1, Z2, Z3, Z4, R8, and R9 are as defined herein. These compounds are selective inhibitors of factor VIIa which can be used as medicaments.